Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines, including leukemia suppressor, granulocyte colony-stimulating factor and interleukin-6. OSM encodes a growth regulator that inhibits the proliferation of a variety of tumor cell lines. It stimulates the proliferation of AIDS-KS cells. OSM regulates cytokines produced by endothelial cells, including IL-6, G-CSF, and GM-CSF. OSM is considered to be a multipotent cytokine that initiates its biological activity through specific cell surface receptors. A low-affinity LIF receptor similar to the protein-containing GP130 has been identified as a component of the high-affinity OSM receptor, which will transmit OSM signals. OSM has also been shown to play a role in promoting and anti-inflammatory effects. OSM may also be involved in many biological metabolic processes, including liver development, hematopoiesis, inflammation, bone formation and destruction, and possibly central nervous system development.
Measured by the dose-dependent stimulation of TF-1 cells. The ED50 for this effect is 0.2-1 ng/ml.
Accession: P13725
APMol Mass: 28 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 20mMTris-HCl, 1mM EDTA, 200mM NaCl, pH 7.5.
| Solubility (25°C) | Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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