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About 30 results found for searched term "CY7" (0.005 seconds)
| Cat.No. | Name | Information |
|---|---|---|
| M1636 | Abiraterone | Abiraterone acetate (CB-7598) is a potent, selective, and orally available inhibitor of CYP17 with an IC50 of 4 nM. |
| M1700 | Momelotinib (CYT387) | Momelotinib (CYT387) is a small-molecule, ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM respectively. |
| M1749 | Gefitinib | Gefitinib (ZD1839) is an EGFR tyrosine kinase and Akt phosphorylation inhibitor. Gefitinib significantly down-regulates CD47 expression and increases DC phagocytosis in non-small cell lung cancer cells such as PC9, H1437 and H1573. Gefitinib combined with CD47 antibody can enhance the phagocytosis of macrophages. |
| M1800 | JNJ-7706621 | JNJ-7706621 is a dual cell cycle inhibitor with activity against cyclin-dependent kinases (CDK1, 2, 3, 6) with an IC50 of 3-175 nM and Aurora kinases (A and B) with an IC50 of 11-15 nM respectively. |
| M1831 | Cyclosporine A | Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin with an IC50 of 7 nM. cyclosporin A [CsA] binds to the cyclophilin 18 (Cyp18)-CsA complex. the Cyp18-CsA complex recruits calcium-regulated neurophosphatase (CaN), leading to the blocking of cytokine gene transcription in activated T cells. CsA is a highly specific inhibitor of T-cell activation. |
| M2001 | Idarubicin | Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells. |
| M2040 | BAY 11-7082 | BAY 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation (IC50 ~ 10 μM). BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). |
| M2052 | Decitabine (5-Aza-2'-deoxycytidine) | Decitabine (5-Aza-2'-deoxycytidine) is a potent inhibitor of DNA methylation for the treatment of myelodysplastic syndromes. |
| M2184 | Indirubin | Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of ~75 nM and 0.19 μM. |
| M2588 | TGR5 Receptor Agonist | TGR5 Receptor Agonist is a potent TGR5(GPCR19) agonist which showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5). |
| M2488 | Capreomycin Sulfate | Capreomycin Sulfate is a cyclic peptide antibiotic and thought to inhibit protein synthesis by binding to the 70S ribosomal unit. |
| M2547 | Cyromazine | Cyromazine is a triazine insect growth regulator used as an insecticide and an acaricide. |
| M2684 | Estradiol Cypionate | Estradiol cypionate is the 17 β-cyclopentylpropinate ester of estradiol, which inhibits ET-1 synthesis via estrogen receptor. |
| M2717 | Galeterone | Galeterone is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. |
| M2762 | Hyoscyamine | Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM. |
| M2849 | Microcystin-LR | Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1. |
| M2911 | Riviciclib hydrochloride (P276-00) | Riviciclib hydrochloride (P276-00) is an effective CDK inhibitor, inhibiting CDK9-CyclinT1, CDK4-cyclin D1, CDK1-Cyclinb with IC50 values of 20 nM, 63 nM, respectively. 79 nM. Riviciclib hydrochloride (P276-00) has anti-tumor activity against Cisplatin resistant cells. |
| M2916 | PD168393 | PD168393 is an irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773; inactive against insulin, PDGFR, FGFR and PKC. |
| M2929 | PF-4981517 | PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits >500-fold selectivity over CYP3A5 and CYP3A7. |
| M3332 | Alizarin | Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.2 μM, 10.0 μM and 2.7 μM, respectively; weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5. |
| M3375 | S-(+)-Rolipram | S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer. |
| M3433 | Nitazoxanide | Nitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM). |
| M3492 | CYT997 | CYT997 is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. |
| M3502 | Testosterone cypionate | Testosterone cypionate is the oil-soluble 17 (beta)-cyclopentylpropionate ester of the androgenic hormone testosterone. |
| M3591 | Abiraterone Acetate | Abiraterone Acetate is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM. |
| M3641 | XL413 | XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM. |
| M3645 | MG149 | MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM). |
| M3827 | CY7 | Cy7 (Sulfo-Cyanine7) is a fluorescence labeling agent (Ex=750 nm, Em=773 nm), used to label proteins, antibodies, peptides, and oligonucleotides. |
| M3926 | Cynaroside | Cynaroside is a flavone, a flavonoid-like chemical compound. It is a 7-O-glucoside of luteolin. |
| M11227 | FM-479 | Fm-479 was a negative control of FM-381 (HY-102046) and showed no activity against JAK3 or other kinases. Fm-381 is a potent covalent reversible inhibitor of JAK3 targeting unique Cys909. For JAK3, FM-381 was 410, 2700 and 3600 times more selective than JAK1, JAK2 and TYK2 with IC50 of 127 pM. |
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