About 30 results found for searched term "CY7" (0.05 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1700 | Momelotinib (CYT387) | JAK |
| LM-1149; Momelotinib; CYT 11387 | ||
| Momelotinib (CYT387) is a small-molecule, ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 and 18 nM respectively. | ||
| M1831 | Cyclosporine A | Immunology/Inflammation |
| Ciclosporin A; CsA; Cyclosporin A; Antibiotic S 7481F1 | ||
| Cyclosporine A (CsA，Cyclosporin A) is an immunosuppressant that binds to cyclophilin and inhibits calcineurin with an IC50 of 7 nM. Cyclosporine A [CsA] binds to the cyclophilin 18 (Cyp18)-CsA complex. the Cyp18-CsA complex recruits calcium-regulated neurophosphatase (CaN), leading to the blocking of cytokine gene transcription in activated T cells. CsA is a highly specific inhibitor of T-cell activation. | ||
| M2052 | Decitabine | DNA Methyltransferase |
| 5-Aza-2'-deoxycytidine; NSC 127716; 5-Aza-dC; 5-AZA-CdR | ||
| Decitabine (5-Aza-2'-deoxycytidine) is a potent inhibitor of DNA methylation for the treatment of myelodysplastic syndromes. | ||
| M2547 | Cyromazine | Metabolite/Endogenous Metabolite |
| Cyromazin; CGA-72662 | ||
| Cyromazine is a triazine insect growth regulator used as an insecticide and an acaricide. | ||
| M2849 | Microcystin-LR | Phosphatase |
| Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa) | ||
| Microcystin-LR is a potent protein phosphatase inhibitor with IC50 of 0.04 nM for PP2A, >40-fold selectivity over PP1. | ||
| M2929 | PF-4981517 | Cytochrome P450 (e.g. CYP17) |
| CYP3cide, PF-04981517 | ||
| PF-4981517 is a potent and selective inhibitor of CYP3A4 (P450) with IC50 of 0.03 μM, exhibits >500-fold selectivity over CYP3A5 and CYP3A7. | ||
| M3492 | CYT997 | Microtubule |
| Lexibulin | ||
| CYT997 is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. | ||
| M3827 | CY7 | Fluorescent Dye |
| Sulfo-Cyanine7 carboxylic acid | ||
| Cy7 (Sulfo-Cyanine7) is a fluorescence labeling agent (Ex=750 nm, Em=773 nm), used to label proteins, antibodies, peptides, and oligonucleotides. | ||
| M4935 | 3-Cyano-7-ethoxycoumarin | Cytochrome P450 (e.g. CYP17) |
| 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage. | ||
| M5122 | DiR iodide | Fluorescent Dye |
| DiIC18(7); Cy7 DiC18 | ||
| DiR is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins. | ||
| M6638 | CY7-SE | Fluorescent Dye |
| Sulfo-Cyanine7 Succinimidyl Ester | ||
| CY7-SE is a near-infrared fluorescent dye for labeling of amines; supplied as NHS ester. | ||
| M8432 | CYM50769 | Neuropeptide Receptor |
| CYM50769 is a potent, specific antagonist of the Neuropeptide B and Neuropeptide W receptor, NPBWR1 (IC50 = 120 nM). | ||
| M9153 | ACY-738 | HDAC |
| ACY-738 is a potent, selective and orally-bioavailable HDAC6 inhibitor, with an IC50s of 1.7 nM. | ||
| M10079 | ACY-775 | HDAC |
| ACY775 | ||
| ACY-775 is a potent and selective HDAC6 inhbiitor with IC50 of 7.5 nM. | ||
| M10233 | ((Cys31,Nva34)-Neuropeptide Y (27-36))2 | Neuropeptide Receptor |
| BWX 46 | ||
| ((Cys31,Nva34)-Neuropeptide Y (27-36))2, also called BWX 46, is a neuropeptide Y (NPY) Y5 receptor selective agonist. | ||
| M10833 | Ibrexafungerp | Anti-infection |
| SCY-078; MK-3118 | ||
| Ibrexafungerp is a novel, orally available glucan synthase inhibitor with in vitro activity against many echinocandin-resistant Candida strains. | ||
| M13671 | ACY-957 | HDAC |
| ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. | ||
| M13852 | Momelotinib sulfate | JAK |
| CYT387 sulfate salt | ||
| Momelotinib sulfate (CYT387 sulfate salt) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, 10-fold selectivity versus JAK3 (IC50=155 nM). In addition, Momelotinib is an inhibitor of activin A receptor type I (ACVR1). It may be used in studies related to myelofibrosis. | ||
| M15040 | Recombinant Human MCP-3/CCL7 (CHO) | Cytokines and Growth Factors |
| C-C motif chemokine 7; Small inducible cytokine A7 | ||
| Chemokine (C-C Motif) Ligand 7 (CCL7) is a small cytokine formerly known as monocyte specific chemokine 3 (McP-3). | ||
| M16351 | 2α-Acetoxy-14,15-cyclopimara-7β,16-diol | Diterpenoids |
| 2α-Acetoxy-14,15-cyclopimara-7β,16-diol | ||
| M16893 | erythro-Guaiacylglycerol β-sinapyl ether 7-O-glucoside | Lignans |
| erythro-Guaiacylglycerol β-sinapyl ether 7-O-glucoside | ||
| M21799 | Acoziborole | Parasite |
| SCYX-7158; AN5568 | ||
| Acoziborole (SCYX-7158) is an effective and orally active antiprotozoal agent for the research of human african trypanosomiasis (HAT). | ||
| M25434 | Tranylcypromine (2-PCPA) HCl (≥97.0%) | Monoamine Oxidase |
| SKF-385 HCl; Trans 2-Phenylcyclopropylamine Hydrochloride | ||
| Tranylcypromine HCl is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively. Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC50s of 20.7, 2.3 and 0.95 μM, respectively. | ||
| M28232 | CYM50179 | LPL Receptor |
| ML-178 | ||
| CYM50179 (ML-178) is a potent and selective S1P4-R (Sphingosine-1-phosphate4 receptor) agonist with an EC50 of 46 nM. | ||
| M30766 | CYM-5478 | LPL Receptor |
| CYM-5478 is a potent and highly selective S1P2 agonist with an EC50 of 119 nM in a TGFα-shedding assay. CYM-5478 protects neural-derived cell lines against Cisplatin toxicity. | ||
| M30903 | Lexibulin dihydrochloride | Microtubule |
| CYT-997 dihydrochloride | ||
| Lexibulin dihydrochloride (CYT-997 dihydrochloride) is a potent and orally active tubulin polymerisation inhibitor with IC50s of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo. Lexibulin dihydrochloride induces cell apoptosis and induces mitochondrial ROS generation in GC cells. | ||
| M31332 | Cyanine7.5 maleimide | Fluorescent Dye |
| Cyanine7.5 maleimide (CY7.5-maleimide) is a commonly used phalloidin dye, and its labeled product has an Ex/Em of 788/808 nm, respectively. | ||
| M43153 | CYCA-117-70 | Ligand for E3 Ligase |
| CYCA-117-70 is a DCAF1 ligand (KD: 70 μM). CYCA-117-70 is an ideal chemical handles for PROTACs recruiting DCAF1. | ||
| M53490 | Cys-TAT(47-57) | Anti-infection |
| Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) is an arginine rich cell penetrating peptide derived from the HIV-1 transactivating protein. | ||
| M53493 | (Cys47)-HIV-1 tat Protein (47-57) | Anti-infection |
| (Cys47)-HIV-1 tat Protein (47-57) has membrane translocation function and can be used to derivatize the surface of magnetic pharmaceuticals and substantially facilitated their uptake into target cells. | ||
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