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ACY-775

Cat. No. M10079
ACY-775 Structure
Synonym:

ACY775

Size Price Availability
10mg USD 210  USD210 4-7 Days
25mg USD 310  USD310 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

ACY-775 is a potent and selective HDAC6 inhbiitor with IC50 of 7.5 nM. ACY-775 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs. ACY-775 shares the antidepressant-like properties of other HDAC inhibitors, such as SAHA and MS-275. ACY-775 (50 mg/kg) administered repeatedly in wild-type mice at 24 h, 4 h, and 30 min before killing significant increases in α-tubulin acetylation are observed in all tested brain regions.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 330.36
Formula C17H19FN4O2
CAS Number 1375466-18-4
Purity >98%
Solubility DMSO ≥ 89 mg/mL
Storage at -20°C
References

[1] Veronick Benoy, et al. Neurotherapeutics. Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease

[2] Jeanine Jochems, et al. Neuropsychopharmacology. Antidepressant-like properties of novel HDAC6-selective inhibitors with improved brain bioavailability

[3] Sridurga Mithraprabhu, et al. Br J Haematol. Histone deacetylase (HDAC) inhibitors as single agents induce multiple myeloma cell death principally through the inhibition of class I HDAC

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ACY-775, ACY775 supplier, HDAC, inhibitors

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