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Ibrexafungerp

Cat. No. M10833
Ibrexafungerp Structure
Synonym:

SCY-078; MK-3118

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Biological Activity

Ibrexafungerp is a novel, orally available glucan synthase inhibitor with in vitro activity against many echinocandin-resistant Candida strains.

Chemical Information
Molecular Weight 730.03
Formula C44H67N5O4
CAS Number 1207753-03-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Arnold Lee. Drugs. Ibrexafungerp: First Approval

[2] No authors listed. J Fungi (Basel). Ibrexafungerp

[3] Sabelle Jallow, et al. J Fungi (Basel). Ibrexafungerp: A First-in-Class Oral Triterpenoid Glucan Synthase Inhibitor

[4] Mahmoud Ghannoum, et al. Antibiotics (Basel). Ibrexafungerp: A Novel Oral Triterpenoid Antifungal in Development for the Treatment of Candida auris Infections

[5] M R Davis, et al. Med Mycol. Ibrexafungerp: A novel oral glucan synthase inhibitor

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Keywords: Ibrexafungerp, SCY-078; MK-3118 supplier, Anti-infection, inhibitors, activators


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