About 32 results found for searched term "5-HT2A" (0.926 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M41730 | 5-HT2A receptor agonist-3 | 5-HT Receptor |
| 5-HT2A receptor agonist-3 is the most selective agonist for the human 5-HT2A receptor yet discovered, with a Ki of 2.5 nM. | ||
| M41736 | 5-HT2A&5-HT2C agonist-1 | 5-HT Receptor |
| 5-HT2A&5-HT2C agonist-1 is a 5-HT2A & 5-HT2C agonist, with IC50s of 196 nM and 0.9 nM respectively. | ||
| M2825 | Lurasidone hydrochloride | 5-HT Receptor |
| SM-13496 | ||
| Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively. | ||
| M3239 | Ketanserin | 5-HT Receptor |
| R41468 | ||
| Ketanserin is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A. | ||
| M3456 | Chlorpromazine hydrochloride | Potassium Channel |
| Sonazine | ||
| Chlorpromazine hydrochloride is an antagonist of D2, 5HT2A, potassium and sodium channels. The Ki of Chlorpromazine Hydrochloride to D2 and 5HT2A were 363 nM and 8.3 nM, respectively. Chlorpromazine also excites the 20S proteasome. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M3659 | Pimavanserin | 5-HT Receptor |
| ACP-103 | ||
| Pimavanserin is a selective serotonin 5-HT2A inverse agonist, with pIC50 and pKd of 8.73 and 9.3, respectively. | ||
| M3772 | SB242084 | 5-HT Receptor |
| SB242084 has a high affinity (pKi 9.0) for the cloned human 5-HT2C receptor and 100- and 158-fold selectivity over the closely related cloned human 5-HT2B and 5-HT2A subtypes respectively. | ||
| M3997 | Nuciferine | 5-HT Receptor |
| Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM). Nuciferine possesses anti-hyperlipidemia, anti-hypotensive, anti-arrhythmic, and insulin secretagogue activities. | ||
| M4281 | Isocorynoxeine | 5-HT Receptor |
| 7-Isocorynoxeine | ||
| Isocorynoxeine, an alkaloid related to uncarline, showed a dose-dependent inhibition of 5-HT2A receptor-mediated current response with an IC50 of 72.4 μM. | ||
| M4741 | Harmine-hydrochloride | DYRK |
| Harmine Hydrochloride (Telepathine Hydrochloride) is a DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine Hydrochloride has a high affinity for 5-HT2A serotonin receptor, with a Ki value of 397 nM. | ||
| M5809 | Nefazodone hydrochloride | 5-HT Receptor |
| BMY-13754; MJ-13754-1 | ||
| Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). | ||
| M5848 | Paliperidone | Dopamine Receptor |
| 9-hydroxyrisperidone | ||
| Paliperidone, the main active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. | ||
| M5935 | Risperidone | 5-HT Receptor |
| R-64766 | ||
| Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively. | ||
| M5951 | Sarpogrelate HCl | 5-HT Receptor |
| MCI-9042 | ||
| Sarpogrelate (MCI-9042) hydrochloride, a selective 5-HT2 antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. | ||
| M8188 | Spiperone | Dopamine Receptor |
| Spiroperidol | ||
| Spiperone is a potent dopamine D2, α1B-adrenoceptor, serotonin 5-HT1A, and serotonin 5-HT2A antagonist. Spiperone has the potential for the research of neurology diseases. | ||
| M8864 | Zotepine | 5-HT Receptor |
| Zotepine is a potent 5-HT2A, 5-HT2C, histamine H1, α1-adrenergic, and dopamine D2 receptor antagonist with Kd values of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. | ||
| M8955 | MIN-101 | 5-HT Receptor |
| Roluperidone; CYR-101 | ||
| MIN-101 (Roluperidone) is a novel compound with affinities for 5-HT2A and sigma-2 receptors with Ki values of 7.53 nM and 8.19 nM, respectively. | ||
| M11167 | A-381393 | Dopamine Receptor |
| A-381393 IS AN EFFECTIVE, SELECTIVE, AND BLOOD-BRAIN BARRIER-PERMEABLE dopamine D4 receptor Antagonist, dopamine D for humans4.4，D4.2 AND D4.7 receptors Ki The values are 1.5, 1.9, and 1.6 nM, respectively, with selectivity being D1，D2，D3，D5 MORE THAN 2700 TIMES THE DOPAMINE RECEPTOR. A-381393 VS. 5-HT2A MODERATE SELECTIVITY, Ki The value is 370 nM. | ||
| M17903 | Gamma-Mangostin | COX |
| γ-Mangostin | ||
| Gamma-Mangostin (γ-Mangostin) is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities. | ||
| M20417 | Flibanserin | 5-HT Receptor |
| BIMT-17, BIMT-17-BS | ||
| Flibanserin is a nonhormonal, centrally acting molecule that acts as an agonist at postsynaptic 5-HT1A receptors and as an antagonist at 5-HT2A receptors. | ||
| M20437 | Perospirone hydrochloride | 5-HT Receptor |
| SM-9018 hydrochloride | ||
| Perospirone is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. | ||
| M20535 | Chlorpromazine | Dopamine Receptor |
| Chlorpromazine is an orally active, blood-brain barrier-transparent D2 dopamine receptors and 5-HT2A antagonist. Chlorpromazine also blocks hNav1.7 channels (IC50=25.9 μM; concentration-dependent) and HERG potassium channels (IC50=21.6 μM). | ||
| M20782 | Pimethixene maleate | 5-HT Receptor |
| Pimetixene maleate | ||
| Pimethixene (Pimetixene) maleate is a highly potent antagonist of a broad range of monoamine receptors, inhibits 5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1B, 5-HT6, 5-HT7, Adrenergic α-1A, Dopamine D1 Receptor, Dopamine D2 Receptor, Dopamine D4.4 Receptor, Histamine H1 Receptor, Muscarinic M1 and Muscarinic M2. | ||
| M20976 | SB 200646 | 5-HT Receptor |
| SB 200646A | ||
| SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo. | ||
| M40960 | Gepirone | 5-HT Receptor |
| BMY-13805 | ||
| Gepirone (Gepirone) is a first-in-class, selective, affinity-based, orally active 5-HT1A receptor partial agonist as well as a 5-HT2A receptor antagonist for use in studies related to anxiety, depression, and chronic kidney disease. | ||
| M27717 | SB 242084 dihydrochloride | 5-HT Receptor |
| SB 242084 dihydrochloride is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 dihydrochloride increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 dihydrochloride also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 dihydrochloride has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage. | ||
| M27904 | Lumateperone tosylate | 5-HT Receptor |
| ITI-007 tosylate | ||
| Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia. | ||
| M28018 | Brilaroxazine | Dopamine Receptor |
| RP5063 | ||
| Brilaroxazine (RP5603) is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator. Brilaroxazine is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki=1.5 nM) and 5-HT2A (Ki=2.5 nM), and has antagonist activity at 5-HT2B (Ki=0.19 nM), and 5-HT7 (Ki=2.7 nM) receptors. | ||
| M28859 | Masupirdine mesylate | 5-HT Receptor |
| SUVN-502 mesylate | ||
| Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites, and has potential for treatment of Alzheimer's disease. | ||
| M28951 | RS-102221 | 5-HT Receptor |
| RS-102221 is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 can promote the differentiation of new nerve cells. RS-102221 increases food-intake and weight-gain in rats. | ||
| M28976 | RS-102221 hydrochloride | 5-HT Receptor |
| RS-102221 hydrochloride is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 hydrochloride shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 hydrochloride can promote the differentiation of new nerve cells. RS-102221 hydrochloride increases food-intake and weight-gain in rats. | ||
| M29070 | Methiothepin maleate | 5-HT Receptor |
| Metitepine maleate; Ro-8-6837 maleate | ||
| Methiothepin maleate is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C). | ||
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