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Lumateperone tosylate

Cat. No. M27904

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Lumateperone tosylate Structure
Synonym:

ITI-007 tosylate

Size Price Availability Quantity
5mg USD 58  USD58 In stock
10mg USD 95  USD95 In stock
25mg USD 185  USD185 In stock
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Quality Control & Documentation
Biological Activity

Lumateperone (ITI-007) tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone tosylate has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia.

Chemical Information
Molecular Weight 565.7
Formula C31H36FN3O4S
CAS Number 1187020-80-9
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage 4°C, dry, sealed
References

[1] Kunal Maini, et al. Health Psychol Res. Lumateperone tosylate, A Selective and Concurrent Modulator of Serotonin, Dopamine, and Glutamate, in the Treatment of Schizophrenia

[2] Joseph R Calabrese, et al. Am J Psychiatry. Efficacy and Safety of Lumateperone for Major Depressive Episodes Associated With Bipolar I or Bipolar II Disorder: A Phase 3 Randomized Placebo-Controlled Trial

[3] Amber Edinoff, et al. Psychopharmacol Bull. Lumateperone for the Treatment of Schizophrenia

[4] Christoph U Correll, et al. JAMA Psychiatry. Efficacy and Safety of Lumateperone for Treatment of Schizophrenia: A Randomized Clinical Trial

[5] Pankhuri Vyas, et al. Expert Opin Pharmacother. An evaluation of lumateperone tosylate for the treatment of schizophrenia

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Keywords: Lumateperone tosylate, ITI-007 tosylate supplier, 5-HT Receptor, inhibitors, activators

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