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SB 200646

Cat. No. M20976

All AbMole products are for research use only, cannot be used for human consumption.

SB 200646 Structure
Synonym:

SB 200646A

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Quality Control & Documentation
Biological Activity

SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.

Chemical Information
Molecular Weight 266.3
Formula C15H14N4O
CAS Number 143797-63-1
Solubility (25°C) DMSO 53 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] A Meneses. Neurobiol Learn Mem. Do serotonin(1-7) receptors modulate short and long-term memory?

[2] Thomas P Blackburn, et al. Synapse. The acute and chronic administration of the 5-HT(2B/2C) receptor antagonist SB-200646A significantly alters the activity of spontaneously active midbrain dopamine neurons in the rat: An in vivo extracellular single cell study

[3] Alfredo Meneses. Cell Mol Neurobiol. Involvement of 5-HT(2A/2B/2C) receptors on memory formation: simple agonism, antagonism, or inverse agonism?

[4] Alfredo Meneses. Neurosci Biobehav Rev. Tianeptine: 5-HT uptake sites and 5-HT(1-7) receptors modulate memory formation in an autoshaping Pavlovian/instrumental task

[5] E S Ellis, et al. Br J Pharmacol. Mediation by 5-hydroxytryptamine2B receptors of endothelium-dependent relaxation in rat jugular vein

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Keywords: SB 200646, SB 200646A supplier, 5-HT Receptor, inhibitors, activators

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