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Perospirone hydrochloride

Cat. No. M20437

All AbMole products are for research use only, cannot be used for human consumption.

Perospirone hydrochloride Structure
Synonym:

SM-9018 hydrochloride

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Biological Activity

Perospirone is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.

Chemical Information
Molecular Weight 463.04
Formula C23H31ClN4O2S
CAS Number 129273-38-7
Solubility (25°C) DMSO 92 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] A Tomillero, et al. Methods Find Exp Clin Pharmacol. Gateways to clinical trials

[2] Ning Ma, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Determination of perospirone by liquid chromatography/electrospray mass spectrometry: application to a pharmacokinetic study in healthy Chinese volunteers

[3] Tsuguka Shiwa, et al. J Pharmacol Sci. Perospirone, a novel antipsychotic agent, hyperpolarizes rat dorsal raphe neurons via 5-HT1A receptor

[4] Y Ohno. Nihon Yakurigaku Zasshi. [Pharmacological characteristics of perospirone hydrochloride, a novel antipsychotic agent]

[5] H Yu, et al. Jpn J Pharmacol. Effects of perospirone, a novel antipsychotic agent, on the dopaminergic neurons in the rat ventral tegmental area

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Keywords: Perospirone hydrochloride, SM-9018 hydrochloride supplier, 5-HT Receptor, inhibitors, activators

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