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TGF-beta/Smad Transforming growth factor beta


Cat.No.  Name Information
M9083 Disitertide Disitertide is a TGF-β1 inhibitor.
M4863 Kartogenin Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
M2328 Pirfenidone Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells. Pirfenidone (AMR69) attenuates CCL2 and CCL12 production in fibrocyte cells.
M40769 Anti-Mouse/Human TGF-β In vivo This Mouse Anti-Human/Mouse TGF-β clone Clone 1D11.16.8 recognizes an epitope on Human/Mouse TGF-β1,2,3.
M25098 Ponsegromab Ponsegromab (PF 06946860) is a potent and selective humanized anti-GDF15 antibody inhibitor with anti-cachexia activity. Ponsegromab binds to GDF15 and prevents the binding of GDF15 to GFRAL, thereby blocking GDF15/GFRAL-mediated signaling. Ponsegromab can be used in the research of cancers.
M14946 LSKL, Inhibitor of Thrombospondin (TSP-1) TFA LSKL, Inhibitor of Thrombospondin (TSP-1) TFA is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist.
M14930 Disitertide diammonium Disitertide (P144) diammonium is a polypeptide inhibitor of transforming growth factor TGFβ1, specifically blocking its interaction with the receptor. Disitertide diammonium was also an inhibitor of PI3K and an inducer of apoptosis.
M10712 BIO-013077-01 BIO-013077-01 is a Pyrazole inhibitor of TGF-β.
M10455 SB-4 SB-4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM.
M9713 SJ000291942 SJ000291942 is a bone morphogenic protein (BMP) signaling activator.
M9522 SRI-011381 SRI-011381 is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.
M9223 R-268712 R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5nM, an approximately 5000-fold more selectivity for ALK5 than p38 mitogen-activated protein kinase (MAPK).
M9088 SRI-011381 hydrochloride SRI-011381 hydrochloride is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.
M8149 SIS3 HCl SIS3 is a novel specific inhibitor of TGF-β1/ALK-5 phosphorylation of Smad3 with an IC50 of 3 µM.
M4563 Norcantharidin Norcantharidin
M3972 Amygdalin Laetrile is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds.
M3918 Asiaticoside Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica.
M43560 DT-6 DT-6 is an effective TGF-β1 inhibitor.
M39853 Dalbergioidin Dalbergioidin, a well-known anthocyanin, ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway. Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM.
M31363 YH14618 YH14618 is a synthetic peptide that is also a TGF-β1 modulator and can be used in studies related to disc degenerative diseases.

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