Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M9083 | Disitertide | Disitertide is a TGF-β1 inhibitor. |
| M4863 | Kartogenin | Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. |
| M2328 | Pirfenidone | Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells. Pirfenidone (AMR69) attenuates CCL2 and CCL12 production in fibrocyte cells. |
| M40769 | Anti-Mouse/Human TGF-β In vivo | This Mouse Anti-Human/Mouse TGF-β clone Clone 1D11.16.8 recognizes an epitope on Human/Mouse TGF-β1,2,3. |
| M25098 | Ponsegromab | Ponsegromab (PF 06946860) is a potent and selective humanized anti-GDF15 antibody inhibitor with anti-cachexia activity. Ponsegromab binds to GDF15 and prevents the binding of GDF15 to GFRAL, thereby blocking GDF15/GFRAL-mediated signaling. Ponsegromab can be used in the research of cancers. |
| M14946 | LSKL, Inhibitor of Thrombospondin (TSP-1) TFA | LSKL, Inhibitor of Thrombospondin (TSP-1) TFA is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist. |
| M14930 | Disitertide diammonium | Disitertide (P144) diammonium is a polypeptide inhibitor of transforming growth factor TGFβ1, specifically blocking its interaction with the receptor. Disitertide diammonium was also an inhibitor of PI3K and an inducer of apoptosis. |
| M10712 | BIO-013077-01 | BIO-013077-01 is a Pyrazole inhibitor of TGF-β. |
| M10455 | SB-4 | SB-4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM. |
| M9713 | SJ000291942 | SJ000291942 is a bone morphogenic protein (BMP) signaling activator. |
| M9522 | SRI-011381 | SRI-011381 is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease. |
| M9223 | R-268712 | R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5nM, an approximately 5000-fold more selectivity for ALK5 than p38 mitogen-activated protein kinase (MAPK). |
| M9088 | SRI-011381 hydrochloride | SRI-011381 hydrochloride is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease. |
| M8149 | SIS3 HCl | SIS3 is a novel specific inhibitor of TGF-β1/ALK-5 phosphorylation of Smad3 with an IC50 of 3 µM. |
| M4563 | Norcantharidin | Norcantharidin |
| M3972 | Amygdalin | Laetrile is a glycoside initially isolated from the seeds of the tree Prunus dulcis, also known as bitter almonds. |
| M3918 | Asiaticoside | Asiaticoside (Madecassol) is the active chemical component of the plant Centella asiatica. |
| M43560 | DT-6 | DT-6 is an effective TGF-β1 inhibitor. |
| M39853 | Dalbergioidin | Dalbergioidin, a well-known anthocyanin, ameliorates doxorubicin-induced renal fibrosis by suppressing the TGF-β signal pathway. Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. |
| M31363 | YH14618 | YH14618 is a synthetic peptide that is also a TGF-β1 modulator and can be used in studies related to disc degenerative diseases. |
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