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TGF-beta/Smad Transforming growth factor beta

Inhibitors

Cat.No.  Name Information
M2108 SB-525334 SB-525334 is a potent activin receptor-like kinase (ALK5)/ type I TGFβ-receptor kinase inhibitor with IC50 of 14.3 nM.
M2081 LY2109761 LY2109761 is a novel TGF-β receptor type I and type II dual inhibitor.
M1980 LY2157299 (Galunisertib) LY2157299 (Galunisertib) is a novel clinically relevant TBRI (ALK5 kinase) inhibitor with IC50 of 56 nM.
M5037 A 83-01 A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively).*The compound is unstable in solutions, freshly prepared is recommended
M2328 Pirfenidone Pirfenidone inhibits TGF-β bioactivity by affecting TGF-β2 mRNA expression and processing of pro-TGF-β in CCL-64 cells.
M14947 pm26TGF-β1 peptide TFA pm26TGF-β1 TFA peptide is a peptide that mimics a portion of the human TGF-β1 molecule.
M14946 LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA) LSKL, Inhibitor of Thrombospondin (TSP-1) TFA is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist.
M14944 Vactosertib Hydrochloride Vactosertib Hydrochloride (EW-7197 Hydrochloride) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC50 of 12.9 nM.
M14943 AZ12601011 AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC50 of 18 nM and a Kd of 2.9 nM.
M14942 ALK2-IN-2 ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) with an IC50 of 9 nM, and over 700-fold selectivity against ALK3.
M14930 Disitertide TFA Disitertide (P144) TFA is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor.
M10596 BIBF0775 BIBF0775 is a potent and selective inhibitor of the transforming growth factor β receptor I (TGFβRI, Alk5) with an IC50 of 34 nM.
M10455 SB-4 SB-4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM.
M9713 SJ000291942 SJ000291942 is a bone morphogenic protein (BMP) signaling activator.
M9683 SM16 SM16 inhibits TGFβ-induced plasminogen activator inhibitor-luciferase activity (IC50=64 nM).
M9522 SRI-011381 SRI-011381 is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.
M9243 ITD-1 ITD-1 is a selective TGFβ receptor inhibitor with an IC50 of about 0.4-0.8 μM.
M9223 R-268712 R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5nM, an approximately 5000-fold more selectivity for ALK5 than p38 mitogen-activated protein kinase (MAPK).
M9222 LY3200882 LY3200882 is a novel, highly selective TGFβRI small molecule inhibitor.
M9088 SRI-011381 hydrochloride SRI-011381 hydrochloride is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.
M9083 Disitertide Disitertide is a TGF-β1 inhibitor.
M8149 SIS3 HCl SIS3 is a novel specific inhibitor of TGF-β1/ALK-5 phosphorylation of Smad3 with an IC50 of 3 µM.
M5246 EW-7197 EW-7197 is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively.
M5038 SD-208 SD-208 is a selective TGF-βRI (ALK5) inhibitor with IC50 of 48 nM, >100-fold selectivity over TGF-βRII.
M5037 A 83-01 A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively).*The compound is unstable in solutions, freshly prepared is recommended



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