Free shipping on all orders over $ 500

SB-4

Cat. No. M10455
SB-4 Structure
Synonym:

BMP signaling agonist sb4

Size Price Availability Quantity
5mg USD 70  USD70 In stock
25mg USD 170  USD170 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

SB-4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM. SB-4 activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 320.20
Formula C14H10BrNOS
CAS Number 100874-08-6
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] Eleftherios Pelechas, et al. Expert Opin Biol Ther. Etanercept biosimilar SB-4

[2] Shayna T J Bradford, et al. J Biol Chem. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds

Related TGF-beta/Smad Products
BIBF0775

BIBF0775 is a potent and selective inhibitor of the transforming growth factor β receptor I (TGFβRI, Alk5) with an IC50 of 34 nM.

SJ000291942

SJ000291942 is a bone morphogenic protein (BMP) signaling activator.

SM16

SM16 inhibits TGFβ-induced plasminogen activator inhibitor-luciferase activity (IC50=64 nM).

SRI-011381

SRI-011381 is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.

ITD-1

ITD-1 is a selective inhibitor of TGF-β signaling (IC50 ~ 0.4-0.8 μM).

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SB-4, BMP signaling agonist sb4 supplier, TGF-beta/Smad, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.