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SB-4

Cat. No. M10455
SB-4 Structure
Synonym:

BMP signaling agonist sb4

Size Price Availability Quantity
5mg USD 70  USD70 In stock
25mg USD 170  USD170 In stock
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Quality Control & Documentation
Biological Activity

SB-4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM. SB-4 activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9.

Chemical Information
Molecular Weight 320.20
Formula C14H10BrNOS
CAS Number 100874-08-6
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Eleftherios Pelechas, et al. Expert Opin Biol Ther. Etanercept biosimilar SB-4

[2] Shayna T J Bradford, et al. J Biol Chem. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds

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Keywords: SB-4, BMP signaling agonist sb4 supplier, TGF-beta/Smad, inhibitors, activators


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