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Stamulumab

Cat. No. M25249

All AbMole products are for research use only, cannot be used for human consumption.

Stamulumab Structure
Synonym:

MYO-029

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Quality Control & Documentation
Biological Activity

Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research.

Chemical Information
CAS Number 705287-60-1
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Mario Thevis, et al. Expert Rev Proteomics. Detecting peptidic drυgs, drυg candidates and analogs in sports doping: current status and future directions

[2] Mario Thevis, et al. J Pharm Biomed Anal. Analytical approaches for the detection of emerging therapeutics and non-approved drυgs in human doping controls

[3] Christian M Girgis, et al. Curr Osteoporos Rep. Therapies for musculoskeletal disease: can we treat two birds with one stone?

[4] Yoshihide Sunada. Rinsho Shinkeigaku. [Anti-myostatin antibody therapy for myopathies]

[5] Amelie Nadeau, et al. Ann Neurol. Are big muscles necessarily good muscles?

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Keywords: Stamulumab, MYO-029 supplier, TGF-beta/Smad, inhibitors, activators

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