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Stamulumab

Cat. No. M25249
Stamulumab Structure
Synonym:

MYO-029

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Quality Control & Documentation
Biological Activity

Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research.

Chemical Information
CAS Number 705287-60-1
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mario Thevis, et al. Expert Rev Proteomics. Detecting peptidic drυgs, drυg candidates and analogs in sports doping: current status and future directions

[2] Mario Thevis, et al. J Pharm Biomed Anal. Analytical approaches for the detection of emerging therapeutics and non-approved drυgs in human doping controls

[3] Christian M Girgis, et al. Curr Osteoporos Rep. Therapies for musculoskeletal disease: can we treat two birds with one stone?

[4] Yoshihide Sunada. Rinsho Shinkeigaku. [Anti-myostatin antibody therapy for myopathies]

[5] Amelie Nadeau, et al. Ann Neurol. Are big muscles necessarily good muscles?

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  Catalog
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Keywords: Stamulumab, MYO-029 supplier, TGF-beta/Smad, inhibitors, activators


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