Free shipping on all orders over $ 500

Stamulumab

Cat. No. M25249
Stamulumab Structure
Synonym:

MYO-029

Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research.

Chemical Information
CAS Number 705287-60-1
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mario Thevis, et al. Expert Rev Proteomics. Detecting peptidic drυgs, drυg candidates and analogs in sports doping: current status and future directions

[2] Mario Thevis, et al. J Pharm Biomed Anal. Analytical approaches for the detection of emerging therapeutics and non-approved drυgs in human doping controls

[3] Christian M Girgis, et al. Curr Osteoporos Rep. Therapies for musculoskeletal disease: can we treat two birds with one stone?

[4] Yoshihide Sunada. Rinsho Shinkeigaku. [Anti-myostatin antibody therapy for myopathies]

[5] Amelie Nadeau, et al. Ann Neurol. Are big muscles necessarily good muscles?

Related TGF-beta/Smad Products
A 83-01 sodium

A 83-01 sodium is a potent inhibitor of TGF-β type I receptors ALK5, ALK4, and ALK7, inhibiting ALK5, ALK4, and ALK7-induced transcription with IC50 values of 12 nM, 45 nM, and 7.5 nM, respectively.

Myristoyl tetrapeptide-12

Myristoyl tetrapeptide-12 directly activates SMAD2 and induces the linking of SMAD3 with DNA.

H-Leu-Ser-Lys-Leu-OH

H-Leu-Ser-Lys-Leu-OH (LSYL) is a latency-associated peptide at the amino terminus of LAP, with inhibitory effect on TGF-β1 activation.

SY-LB-35

SY-LB-35 is a potent bone morphogenetic protein (BMP) receptor agonist.

DT-6

DT-6 is an effective TGF-β1 inhibitor.

  Catalog
Abmole Inhibitor Catalog




Keywords: Stamulumab, MYO-029 supplier, TGF-beta/Smad, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.