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Lerdelimumab

Cat. No. M25204
Lerdelimumab Structure
Synonym:

CAT-152

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Quality Control & Documentation
Biological Activity

Lerdelimumab (CAT-152) is an IgG4 human anti-TGF-β2 recombinant monoclonal antibody. Lerdelimumab can be used as an anti-scarring agent for glaucoma research.

Chemical Information
CAS Number 285985-06-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dominique Bonafoux, et al. Expert Opin Ther Pat. Strategies for TGF-beta modulation: a review of recent patents

[2] Yves Lachkar, et al. Ophthalmology. Trabeculectomy outcomes

[3] M Bayes, et al. Methods Find Exp Clin Pharmacol. Gateways to clinical trials

[4] M Francesca Cordeiro. Curr Opin Mol Ther. Technology evaluation: lerdelimumab, Cambridge Antibody Technology

[5] No authors listed. Drugs R D. Lerdelimumab

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Keywords: Lerdelimumab, CAT-152 supplier, TGF-beta/Smad, inhibitors, activators


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