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Metelimumab

Cat. No. M25202
Metelimumab Structure
Synonym:

CAT-192; Anti-TGFB1 Recombinant Antibody

Size Price Availability
1mg USD 280  USD280 3-4 Weeks
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Quality Control & Documentation
Biological Activity

Metelimumab (CAT-192) is a human IgG4 monoclonal antibody that can selectively neutralize TGFβ1.

Chemical Information
CAS Number 272780-74-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dana M Lord, et al. MAbs. Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGFβ1 antibody

[2] Dominique Bonafoux, et al. Expert Opin Ther Pat. Strategies for TGF-beta modulation: a review of recent patents

[3] G Lappin, et al. J Pharm Biomed Anal. Novel use of accelerator mass spectrometry for the quantification of low levels of systemic therapeutic recombinant protein

[4] M Bayés, et al. Methods Find Exp Clin Pharmacol. Gateways to clinical trials

[5] M Bayés, et al. Methods Find Exp Clin Pharmacol. Gateways to clinical trials

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Keywords: Metelimumab, CAT-192; Anti-TGFB1 Recombinant Antibody supplier, TGF-beta/Smad, inhibitors, activators


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