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SRI-011381

Cat. No. M9522
SRI-011381 Structure
Size Price Availability Quantity
10mg USD 190  USD190 In stock
25mg USD 295  USD295 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

SRI-011381 is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 329.48
Formula C20H31N3O
CAS Number 1629138-41-5
Purity >99%
Solubility DMSO ≥ 40 mg/mL
Storage at -20°C
References

[1] Yuan Liu, et al. Int J Biol Sci. Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SRI-011381 supplier, TGF-beta/Smad, inhibitors

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