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SRI-011381

Cat. No. M9522
SRI-011381 Structure
Size Price Availability Quantity
5mg USD 80  USD80 In stock
10mg USD 140  USD140 In stock
25mg USD 290  USD290 In stock
50mg USD 480  USD480 In stock
100mg USD 780  USD780 In stock
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Quality Control & Documentation
Biological Activity

SRI-011381 is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.

Chemical Information
Molecular Weight 329.48
Formula C20H31N3O
CAS Number 1629138-41-5
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yuan Liu, et al. Int J Biol Sci. Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT.

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  Catalog
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Keywords: SRI-011381 supplier, TGF-beta/Smad, inhibitors, activators


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