| Cat.No. | Name | Information |
|---|---|---|
| M10459 | MSA-2 | MSA-2 is an orally available non-nucleotide STING agonist with antitumor activity. MSA-2 shows EC50 values of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. |
| M9893 | C-176 | C-176 is a potent, selective and blood-brain barrier permeable inhibitor of STING. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING. |
| M56404 | SN-011 | SN-011 is a potent and selective mouse and human STING inhibitor, with an IC50 of 76 nM for STING signaling. |
| M21652 | SN-001 | SN-001 is a STING inhibitor with an IC50 of 3.82 μM. SN-001 targets the cyclic dinucleotide binding pocket of human STING. |
| M14125 | STING-IN-2 | STING-IN-2 (C-170) is a potent and covalent STING inhibitor. STING-IN-2 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). STING-IN-2 can be used for autoinflammatory disease research. |
| M14123 | diABZI | diABZI (Diamidobenzimidazole STING Agonist-1) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
| M14121 | Cyclic-di-GMP | Cyclic-di-GMP (c-di-GMP) is a STING activator and a ubiquitous second messenger that regulates biofilm formation, motility, and virulence in diverse bacterial species. |
| M14120 | cGAMP disodium | cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. |
| M14119 | cGAMP diammonium | cGAMP (Cyclic GMP-AMPP) diammonium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. |
| M11332 | diABZI trihydrochloride | diABZI (STING agonist-1) trihydrochloride is a selective agonist of interferon gene-stimulated receptor (STING), with EC50 scores of 130 nM and 186 nM in mice and humans, respectively. |
| M10766 | ADU-S100 disodium salt | ADU-S100 disodium salt (MIW815 disodium salt) is an activator (STING) of interferon gene stimulators with potent antitumor and immune activity. |
| M10765 | ADU-S100 ammonium salt | ADU-S100 ammonium salt (MIW815 ammonium salt) is an activator (STING) of interferon gene stimulators with potent antitumor and immune activity. |
| M10299 | c-di-AMP | c-di-AMP (Cyclic diadenylate) is a STING agonist, it binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway. |
| M10126 | H-151 | H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation. |
| M10125 | C-178 | C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation. |
| M9923 | SR-717 | SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. |
| M9729 | diABZI (tautomerism) | diABZI (STING agonist 1; Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
| M9453 | 3′3′-cGAMP | 3',3'-cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. 3',3'-cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators. |
| M9084 | STING-Inducer-1 | STING-Inducer-1 (ML RR-S2 CDA) is an inducer of STING (stimulator of interferon genes). |
| M6739 | G10 | G10 is a activator of STING-dependent signaling. |
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