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H-151

Cat. No. M10126
H-151 Structure
Synonym:

H151

Size Price Availability Quantity
5mg USD 87 In stock
10mg USD 131 In stock
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Quality Control
Biological Activity

H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation. H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells. H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 279.34
Formula C17H17N3O
CAS Number 941987-60-6
Purity >99%
Solubility DMSO ≥ 100 mg/mL
Storage -20°C, dry, sealed
References

Targeting STING with covalent small-molecule inhibitors
Simone M Haag, et al. Nature. 2018 Jul;559(7713):269-273. PMID: 29973723.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: H-151, H151 supplier, STING, inhibitors

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