| Cat.No. | Name | Information |
|---|---|---|
| M10459 | MSA-2 | MSA-2 is an orally available non-nucleotide STING agonist with antitumor activity. MSA-2 shows EC50 values of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. |
| M42059 | F-CRI1 | F-CRI1 is a potent STING agonist with a Kd value of 40.62 nM. |
| M42058 | STING agonist-31 | STING agonist-31 is a STING agonist, with EC50 values of 0.24 and 39.51 μM for h-STING and m-STING. |
| M42057 | BI 7446 | BI 7446 is a cyclic dinucleotide (CDN)-based potent and selective stimulator of interferon genes (STING) agonist. |
| M42056 | STING agonist-8 dihydrochloride | STING agonist-8 dihydrochloride is a potent STING agonist with an EC50 of 27 nM in THP1-Dual KI-hSTING-R232 cells. |
| M40559 | MK-2118 | MK-2118 is a STING1 agonist that can be used in studies related to lymphoma. |
| M40558 | GSK3745417 | GSK3745417 is a STING1 agonist that can be used in tumor-related studies. |
| M40557 | SNX281 | SNX281 is a STING1 agonist that can be used in studies related to solid tumors. |
| M40556 | IMSA101 | IMSA101 is a STING1 agonist that can be used in studies related to solid tumors. |
| M40555 | BI1387446 | BI1387446 is a STING1 agonist that can be used in studies related to solid tumors. |
| M40554 | SB11285 | SB11285 is a STING1 stimulator that can be used in melanoma related studies. |
| M29813 | PROTAC STING Degrader-1 | PROTAC STING Degrader-1 (Compound SP23) is a STING PROTAC degrader with a DC50 of 3.2 μM. PROTAC STING Degrader-1 shwos anti-inflammatory activity. |
| M29779 | BSP16 | BSP16 is a potent, orally active stimulator of interferon genes (STING) agonist. BSP16 can selectively stimulate the STING pathway. BSP16 can be used for the research of cancer. |
| M29704 | Dazostinag disodium | Dazostinag disodium (TAK-676) is an agonist of STING, triggering the activation of STING signaling pathway and type I interferons. Dazostinag disodium is also a modulator of immune system, resulting complete regressions and durable memory T-cell immunity. Dazostinag disodium promotes durable IFN-dependent antitumor immunity. |
| M29703 | Dazostinag | Dazostinag (TAK-676 free base) is an agonist of stimulator of interferon genes (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis antibody-drug conjugates (ADCs). |
| M29556 | SR-717 free acid | SR-717 free acid is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity. |
| M29463 | STING agonist-12 | STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM. |
| M29290 | STING agonist-4 | STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function. |
| M21115 | E7766 diammonium salt | E7766 diammonium salt is a macrocyclic bridging STING agonist with a Kd of 40 nM. It has potent pan-genotypic and antitumor activity. |
| M21074 | Ulevostinag | Ulevostinag (MK-1454 ) is an intratumoral stimulator (STING) agonist of the interferon (IFN) gene that is being developed for the study of advanced solid tumors and lymphomas. |
| M20842 | C-171 | C-171 is a covalent small-molecule inhibitor of STING. C-171 efficiently inhibits both hsSTING and mmSTING through covalently target the predicted transmembrane cysteine residue 91 and thereby block the activation-induced palmitoylation of STING. |
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