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Cat. No. M9084
STING-Inducer-1 Structure


Size Price Availability
1mg USD 280 1-2 Weeks
5mg USD 960 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

STING-Inducer-1 has enhanced binding affinity to STING and activate all known human STING alleles. STING-Inducer-1 induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C. ML RR-S2 CDA is also found to induce aggregation of STING and induce phosphorylation of TBK1 and IRF3 in mouse bone marrow macrophage (BMM). ML RR-S2 CDA induces significantly higher levels of IFN-α when compared to ML cGAMP.

In vivo, STING-Inducer-1 shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the ML RR-S2 CDA compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8+ T cell responses, and improves long-term survival to 50%.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 690.54
Formula C20H24N10O10P2S2
CAS Number 1638241-89-0
Purity >99%
Solubility Water ≥ 10 mg/mL
Storage at -20°C

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.
Corrales L, et al. Cell Rep. 2015 May 19;11(7):1018-30. PMID: 25959818.

Related STING Products

c-di-AMP (Cyclic diadenylate) is a STING agonist, it binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway.


H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation.


C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation.


SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively.


C-176 is a potent small-molecule inhibitor of STING.

Abmole Inhibitor Catalog 2017

Keywords: STING-Inducer-1, ML RR-S2 CDA supplier, STING, inhibitors

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