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C-176 is a potent, selective and blood-brain barrier permeable inhibitor of STING. STING is a central signaling component of the intracellular DNA sensing pathway. C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.
C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity. C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1−/− mice.
ACS Nano. 2025 Jan 07.
Platinum(IV)-Backboned Polymer Prodrug-Functionalized Manganese Oxide Nanoparticles for Enhanced Lung Cancer Chemoimmunotherapy via Amplifying Stimulator of Interferon Genes Activation
C-176 purchased from AbMole
| Molecular Weight | 358.09 |
| Formula | C11H7IN2O4 |
| CAS Number | 314054-00-7 |
| Solubility (25°C) | DMSO 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Simone M Haag, et al. Nature. Targeting STING with covalent small-molecule inhibitors.
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