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C-176

Cat. No. M9893
C-176 Structure
Synonym:

C176

Size Price Availability Quantity
10mg USD 155 In stock
50mg USD 325 In stock
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Quality Control
Biological Activity

C-176 is a potent small-molecule inhibitor of STING. STING is a central signaling component of the intracellular DNA sensing pathway.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 358.09
Formula C11H7IN2O4
CAS Number 314054-00-7
Purity >98%
Solubility DMSO 60 mg/mL
Storage at -20°C
References

Targeting STING with covalent small-molecule inhibitors.
Simone M Haag, et al. Nature. 2018 Jul;559(7713):269-273. PMID: 29973723.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: C-176, C176 supplier, STING, inhibitors

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