About 19 results found for searched term "C-176" (0.118 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2007 | Romidepsin (FK228) | HDAC |
| FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 | ||
| Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M2032 | Vicriviroc Malate | CCR |
| SCH 417690 | ||
| Vicriviroc (SCH 417690) is a pyrimidine CCR5 entry inhibitor of HIV-1 with IC50 of 0.91 nM. | ||
| M9893 | C-176 | STING |
| C176 | ||
| C-176 is a potent, selective and blood-brain barrier permeable inhibitor of STING. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING. | ||
| M30343 | Vicriviroc maleate | CCR |
| SCH-417690 maleate; SCH-D maleate | ||
| Vicriviroc maleate (SCH-417690 maleate; SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells, with IC90s of 3.3 nM (JrFL), 2.8 nM (ADA-M), 1.8 nM (301657), 4.9 nM (JV1083) and 10 nM (RU 570). | ||
| M1875 | PD173074 | FGFR |
| PD173074 is a selective FGFR1 and FGFR3 inhibitor with IC50 values of 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively. | ||
| M3293 | HMN-214 | PLK |
| IVX-214 | ||
| HMN-214 is a procompound of HMN-176, which alters the cellular spatial orientation of Plk1. | ||
| M11444 | ABBV-CLS-484 | Phosphatase |
| Osunprotafib; AC484 | ||
| ABBV-CLS-484 (Osunprotafib) is an first-in-class, orally active, potent PTPN2/PTPN1 active site inhibitor with an EC50 of 0.176 μM that enhances the sensitivity of tumor cells to IFNγ and promotes T cell activation and function. | ||
| M24718 | Rinucumab | VEGFR/PDGFR |
| REGN 2176 | ||
| Rinucumab (REGN 2176), a monoclonal antibody, is a PDGF inhibitor. Rinucumab (REGN 2176) could be used for the study of neovascular age-related macular degeneration. | ||
| M28580 | Sonlicromanol | ROS |
| KH176 | ||
| Sonlicromanol (KH176) is an orally active reactive oxygen species (ROS) modulator for the study in mitochondrial disease. | ||
| M29126 | PD176252 | Bombesin Receptor |
| PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells. | ||
| M29312 | Sonlicromanol hydrochloride | ROS |
| KH176 hydrochloride | ||
| Sonlicromanol (KH176) hydrochloride, a chemical entity derivative of Trolox, is a blood-brain barrier permeable ROS-redox modulator. Sonlicromanol (KH176) hydrochloride is used in the study for mitochondrial disorders. | ||
| M29701 | Ataciguat | Guanylate Cyclase |
| HMR-1766 | ||
| Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects. | ||
| M29712 | TH1760 | Others |
| TH1760 is an inhibitor of NUDIX-type 15 (NUDT15) with an IC50 value of 25 nM. TH1760 sensitizes cells to 6-thioguanine by enhancing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 enhances the anti-leukemia effect of thiopurine. | ||
| M42282 | Dehydroglyasperin D | Aldose Reductase |
| Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). | ||
| M42637 | SB-1436 | AChR/AChE |
| SB-1436 is an Cholinesterase (ChE) inhibitor, inhibits AChE, BChE and rHuAChE with IC50s of 0.176, 0.37 and 0.08 μM, respectively. | ||
| M49403 | Relutrigine | Sodium Channel |
| PRAX-562 | ||
| Relutrigine is an orally active, persistent sodium channel inhibitor that potently and preferentially inhibits persistent INa induced by ATX-II (Nav 1.5 activator) or the SCN8A mutation N1768D with IC50 values of 141 nM and 75 nM, respectively. | ||
| M55651 | IM176OUT05 | Mitochondrial Related |
| IM176OUT05 activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process. IM176OUT0 inhibits mitochondrial electron transport chain (ETC) activity with an IC50 of 3.2 μM. IM176OUT05 is a high solubility biguanide. | ||
| M56358 | Dazucorilant | GCR |
| Dazucorilant (CORT113176) is a selective and high affinity non-steroidal glucocorticoid receptor (GR) modulator with a Ki value ＜1 nM in vitro. | ||
| M55843 | Lumicitabine | RSV |
| Lumicitabine (ALS-008176) is an inhibitor of the respiratory syncytial virus (RSV) polymerase. | ||
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