About 16 results found for searched term "C-176" (0.322 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2007 | Romidepsin (FK228) | HDAC |
| FK228; ISTODAX; Depsipeptide; FR 901228; NSC 630176 | ||
| Romidepsin (FK228, Depsipeptide, FR 901228, NSC 630176) is a structurally unique, potent HDAC1 and HDAC2 inhibitor with IC50 of 36 nM and 47 nM, respectively.*The compound is unstable in solutions, freshly prepared is recommended | ||
| M2032 | Vicriviroc Malate | CCR |
| SCH 417690 | ||
| Vicriviroc (SCH 417690) is a pyrimidine CCR5 entry inhibitor of HIV-1 with IC50 of 0.91 nM. | ||
| M9893 | C-176 | STING |
| C176 | ||
| C-176 is a potent small-molecule inhibitor of STING. | ||
| M30343 | Vicriviroc maleate | CCR |
| SCH-417690 maleate; SCH-D maleate | ||
| Vicriviroc maleate (SCH-417690 maleate; SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells, with IC90s of 3.3 nM (JrFL), 2.8 nM (ADA-M), 1.8 nM (301657), 4.9 nM (JV1083) and 10 nM (RU 570). | ||
| M1875 | PD173074 | FGFR |
| PD173074 is a selective FGFR1 and FGFR3 inhibitor with IC50 values of 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively. | ||
| M3293 | HMN-214 | PLK |
| IVX-214 | ||
| HMN-214 is a procompound of HMN-176, which alters the cellular spatial orientation of Plk1. | ||
| M11444 | ABBV-CLS-484 | Phosphatase |
| Osunprotafib; AC484 | ||
| ABBV-CLS-484 (Osunprotafib) is an first-in-class, orally active, potent PTPN2/PTPN1 active site inhibitor with an EC50 of 0.176 μM that enhances the sensitivity of tumor cells to IFNγ and promotes T cell activation and function. | ||
| M24718 | Rinucumab | VEGFR/PDGFR |
| REGN 2176 | ||
| Rinucumab (REGN 2176), a monoclonal antibody, is a PDGF inhibitor. Rinucumab (REGN 2176) could be used for the study of neovascular age-related macular degeneration. | ||
| M28580 | Sonlicromanol | ROS |
| KH176 | ||
| Sonlicromanol (KH176) is an orally active reactive oxygen species (ROS) modulator for the study in mitochondrial disease. | ||
| M29126 | PD176252 | Bombesin Receptor |
| PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells. | ||
| M29312 | Sonlicromanol hydrochloride | ROS |
| KH176 hydrochloride | ||
| Sonlicromanol (KH176) hydrochloride, a chemical entity derivative of Trolox, is a blood-brain barrier permeable ROS-redox modulator. Sonlicromanol (KH176) hydrochloride is used in the study for mitochondrial disorders. | ||
| M29701 | Ataciguat | Guanylate Cyclase |
| HMR-1766 | ||
| Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects. | ||
| M29712 | TH1760 | Others |
| TH1760 is an inhibitor of NUDIX-type 15 (NUDT15) with an IC50 value of 25 nM. TH1760 sensitizes cells to 6-thioguanine by enhancing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 enhances the anti-leukemia effect of thiopurine. | ||
| M42282 | Dehydroglyasperin D | Aldose Reductase |
| Dehydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50: 62.4 μM and 176.2 μM respectively). | ||
| M42637 | SB-1436 | AChR/AChE |
| SB-1436 is an Cholinesterase (ChE) inhibitor, inhibits AChE, BChE and rHuAChE with IC50s of 0.176, 0.37 and 0.08 μM, respectively. | ||
| M49403 | Relutrigine | Sodium Channel |
| PRAX-562 | ||
| Relutrigine is an orally active, persistent sodium channel inhibitor that potently and preferentially inhibits persistent INa induced by ATX-II (Nav 1.5 activator) or the SCN8A mutation N1768D with IC50 values of 141 nM and 75 nM, respectively. | ||
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
