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Vicriviroc maleate (SCH-417690 maleate; SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells, with IC90s of 3.3 nM (JrFL), 2.8 nM (ADA-M), 1.8 nM (301657), 4.9 nM (JV1083) and 10 nM (RU 570).
| Molecular Weight | 649.7 |
| Formula | C32H42F3N5O6 |
| CAS Number | 599179-03-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 50 mg/mL (ultrasonic) Water 25 mg/mL (Need ultrasonic and warming) |
| Storage | 4°C, dry, sealed |
[1] A Tomillero, et al. Methods Find Exp Clin Pharmacol. Gateways to clinical trials
[2] A Tomillero, et al. Methods Find Exp Clin Pharmacol. Gateways to clinical trials
[3] A Tomillero, et al. Methods Find Exp Clin Pharmacol. Gateways to clinical trials
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