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CCR C-C motif receptor

Inhibitors

Cat.No.  Name Information
M7224 RS 504393 RS 504393 is a highly selective CCR2 chemokine receptor antagonist.
M21145 BMS-753426 BMS-753426 is an orally effective CCR2 antagonist.
M20858 DAPTA DAPTA is a water soluble potent, selective CCR5 antagonist which potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5.
M20822 PF-4136309 PF-4136309 (INCB8761, PF-04136309) is a potent, selective, and orally bioavailable CCR2 antagonist with an IC50 of 5.2 nM for human CCR2.
M20778 R243 R243 is an inhibitor of Chemokine (C-C motif) receptor 8 (CCR8) signaling and chemotaxis.
M20618 ZK756326 2HCl ZK756326 is a full agonist of CCR8(Chemokine receptor 8) with an IC50 of 1.8 μM, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1.
M13930 Vercirnon sodium Vercirnon (GSK1605786A) sodium is an orally bioavailable, selective, and potent antagonist of CCR9.
M13929 Vercirnon Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist of CCR9.
M13928 CCR2 antagonist 4 CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM.
M13927 TAK-220 TAK-220 is a selective and orally bioavailable CCR5 antagonist, with IC50s of 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively, but shows no effect on the binding to CCR1, CCR2b, CCR3, CCR4, or CCR7; TAK-220 also selectively inhibits HIV-1, with EC50s of 1.2 nM (HIV-1 KK), 0.72 nM (HIV-1 CTV), 1.7 nM (HIV-1 HKW), 1.7 nM (HIV-1 HNK), 0.93 nM (HIV-1 HTN), and 0.55 nM (HIV-1 HHA).
M13926 INCB3344 INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity.
M13925 GW 766994 GW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research.
M13924 CCR6 inhibitor 1 CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM).
M13923 CCR2-RA-[R] CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC50 of 103 nM.
M13922 BX471 hydrochloride BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with Ki of 1 nM for human CCR1, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
M13921 AZD2098 AZD2098 is a potent and selective CC-chemokine receptor 4 (CCR4) inhibitor with pIC50s of 7.8, 8.0, 8.0 and 7.6 for human, rat, mouse and dog respectively, used for asthma research.
M13920 AZ084 AZ084 is a potent, selective, allosteric and oral active CCR8 antagonist, with a Ki of 0.9 nM. Has potential to treat asthma.
M11028 RS102895 RS102895 is a potent CCR2 antagonist,IC50 The value is 360 nM .
M10190 Cenicriviroc Cenicriviroc, also known as TAK-652 and TBR-652, is an orally active, dual antagonist of CCR2/CCR5.
M9944 7,4'-Dihydroxyflavone 7,4'-Dihydroxyflavone, a flavonoid isolated from Glycyrrhiza uralensis, is an eotaxin/CCL11 inhibitor.
M9884 INCB3284 INCB3284 is a potent, selective, and orally bioavailable hCCR2 antagonist, exhibited an IC50 of 3.7 nM in antagonism of monocyte chemoattractant protein-1 binding to hCCR2.



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