All AbMole products are for research use only, cannot be used for human consumption.
BMS-813160 is the first dual CCR2/CCR5 antagonist. BMS-813160 binds with CCR2, CCR5, CCR1, CCR4 and CXCR2 with IC50s of 6.2 nM, 3.6 nM, ＞25 μM, ＞40 μM and ＞40 μM, respectively.
BMS-813160 (10-160 mg/kg; p.o. twice a day for two days) inhibits the migration of inflammatory monocytes and macrophages in mouse thioglycollate-induced peritonitis model, and shows excellent oral bioavailability.
| Molecular Weight | 484.64 |
| Formula | C25H40N8O2 |
| CAS Number | 1286279-29-5 |
| Solubility (25°C) | DMSO 20 mg/mL Ethanol 70 mg/mL |
| Storage | -20°C, protect from light |
| Related CCR Products |
|---|
| C-021 dihydrochloride
C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. |
| C-021
C-021 is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. |
| AZD-5672
AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). |
| MLN3126
MLN3126 is an orally active and potent CCR9 antagonist. |
| AZD2423
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
