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BMS-813160

Cat. No. M6249
BMS-813160  Structure
Size Price Availability Quantity
5mg USD 280  USD280 In stock
10mg USD 450  USD450 In stock
50mg USD 1350  USD1350 In stock
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Quality Control & Documentation
Biological Activity

BMS-813160 is the first dual CCR2/CCR5 antagonist to enter clinical development for cardiovascular.

Chemical Information
Molecular Weight 484.64
Formula C25H40N8O2
CAS Number 1286279-29-5
Solubility (25°C) 19 mg/mL in DMSO
Storage -20°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Norman P, et al. Expert Opin Ther Pat. A dual CCR2/CCR5 chemokine antagonist, BMS-813160? Evaluation of WO2011046916.

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