Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M7224 | RS 504393 | RS 504393 is a highly selective CCR2 chemokine receptor antagonist, with IC50 values of 89 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors, respectively. |
| M1971 | Maraviroc | Maraviroc (UK-427857) is a selective CCR5 antagonist with potent anti-human immunodeficiency virus type 1 (HIV-1) activity and favorable pharmacological properties. |
| M6249 | BMS-813160 | BMS-813160 is the first dual CCR2/CCR5 antagonist. BMS-813160 binds with CCR2, CCR5, CCR1, CCR4 and CXCR2 with IC50s of 6.2 nM, 3.6 nM, ＞25 μM, ＞40 μM and ＞40 μM, respectively. |
| M13922 | BX471 hydrochloride | BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with Ki of 1 nM for human CCR1, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. |
| M13921 | AZD2098 | AZD2098 is a potent and selective CC-chemokine receptor 4 (CCR4) inhibitor with pIC50s of 7.8, 8.0, 8.0 and 7.6 for human, rat, mouse and dog respectively, used for asthma research. |
| M13920 | AZ084 | AZ084 is a potent, selective, allosteric and oral active CCR8 antagonist, with a Ki of 0.9 nM. Has potential to treat asthma. |
| M11028 | RS102895 | RS102895 is a potent CCR2 antagonist,IC50 The value is 360 nM . |
| M10190 | Cenicriviroc | Cenicriviroc, also known as TAK-652 and TBR-652, is an orally active, dual antagonist of CCR2/CCR5. |
| M9944 | 7,4'-Dihydroxyflavone | 7,4'-Dihydroxyflavone, a flavonoid isolated from Glycyrrhiza uralensis, is an eotaxin/CCL11 inhibitor. |
| M9884 | INCB3284 | INCB3284 is a potent, selective, and orally bioavailable hCCR2 antagonist, exhibited an IC50 of 3.7 nM in antagonism of monocyte chemoattractant protein-1 binding to hCCR2. |
| M9444 | Cenicriviroc Mesylate | Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, and it also inhibits both HIV-1 and HIV-2. |
| M9135 | TAK-779 | TAK-779 is a potent and selective nonpeptide antagonist of CCR5, with a Ki of 1.1 nM for CCR5. |
| M9131 | ZK-756326 dihydrochloride | ZK-756326 dihydrochloride is a potent, selective and non-peptide CCR8 chemokine receptor agonist. |
| M9006 | NSC5844 | NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic properties. |
| M8986 | CCX140 | CCX140 is a potent CCR2 antagonist. |
| M8257 | SB 328437 | SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM. SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. SB 328437 suppresses the Th2-mediated eosinophil infiltration in the airways. |
| M8254 | SB 297006 | SB 297006 is an antagonist of CCR3 with IC50 of 39 nM. |
| M7218 | RS102895 hydrochloride | RS102895 hydrochloride is a cCR2b chemokine receptor antagonist. |
| M6840 | J-113863 | J-113863 is a potent CCR1 chemokine receptor antagonist with IC50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively. J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). |
| M6547 | BX 471 | BX 471 is a potent, selective CCR1 antagonist. |
| M6263 | INCB3284 dimesylate | INCB 3284 dimesylate is a potent, selective and orally bioavailable hCCR2 antagonist with IC50 of 3.7 nM. |
| M2098 | Bindarit | Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8. Bindarit also has anti-inflammatory activity. |
| M2032 | Vicriviroc Malate | Vicriviroc (SCH 417690) is a pyrimidine CCR5 entry inhibitor of HIV-1 with IC50 of 0.91 nM. |
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