Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M7224 | RS 504393 | RS 504393 is a highly selective CCR2 chemokine receptor antagonist, with IC50 values of 89 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors, respectively. |
| M9131 | ZK-756326 dihydrochloride | ZK-756326 dihydrochloride is a potent, selective and non-peptide CCR8 chemokine receptor agonist. |
| M9006 | NSC5844 | NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic properties. |
| M8986 | CCX140 | CCX140 is a potent CCR2 antagonist. |
| M8257 | SB 328437 | SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM. SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. SB 328437 suppresses the Th2-mediated eosinophil infiltration in the airways. |
| M8254 | SB 297006 | SB 297006 is an antagonist of CCR3 with IC50 of 39 nM. |
| M7218 | RS102895 hydrochloride | RS102895 hydrochloride is a cCR2b chemokine receptor antagonist. |
| M6547 | BX 471 | BX 471 is a potent, selective CCR1 antagonist. |
| M6263 | INCB3284 dimesylate | INCB 3284 dimesylate is a potent, selective and orally bioavailable hCCR2 antagonist with IC50 of 3.7 nM. |
| M6249 | BMS-813160 | BMS-813160 is the first dual CCR2/CCR5 antagonist. BMS-813160 binds with CCR2, CCR5, CCR1, CCR4 and CXCR2 with IC50s of 6.2 nM, 3.6 nM, ＞25 μM, ＞40 μM and ＞40 μM, respectively. |
| M2098 | Bindarit | Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8. Bindarit also has anti-inflammatory activity. |
| M2032 | Vicriviroc Malate | Vicriviroc (SCH 417690) is a pyrimidine CCR5 entry inhibitor of HIV-1 with IC50 of 0.91 nM. |
| M1971 | Maraviroc | Maraviroc (UK-427857) is a selective CCR5 antagonist with potent anti-human immunodeficiency virus type 1 (HIV-1) activity and favorable pharmacological properties. |
| M55323 | JBH492 | JBH492 is a first-in-class (C-C chemokine receptor 7) CCR7-targeting ADC, comprising a humanized, Fc-silenced anti-CCR7 IgG1 antibody conjugated to maytansinoid microtubule inhibitor DM4 via a cleavable linker. |
| M54587 | IPG7236 | IPG7236 is a selective CCR8 antagonist that also exhibits significant tumor suppression in a mouse xenograft model of human breast cancer.IPG7236 can be used in cancer-related studies. |
| M53871 | CKLF1-C19 | CKLF1-C19 is the C-terminal peptide of human chemokine-like factor 1 (CKLF1). |
| M53231 | Met-RANTES (human) | Met-RANTES (human) is a partial antagonist of CCR5. |
| M50169 | IPG0521 | IPG0521 is a bifunctional antibody targeting CCR8, which can block CCR8 signaling with high intensity and weak ADCC function, and can effectively inhibit the growth of multiple tumor types in homologous and immunohumanized mouse models. |
| M50168 | IPGA05 | IPGA05 is a monoclonal antibody targeting CCR8 for tumor-related studies. |
| M50167 | PSB-114 | PSB-114 is an ADCC-enhanced targeted CCR8 humanized monoclonal antibody that removes tumor-associated CCR8-expressing Tregs and can be used in tumor-related studies. |
| M50166 | ZL-1218 | ZL-1218 is a novel anti-CCR8 antibody that can be used in studies related to solid tumors. |
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