Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M7224 | RS 504393 | RS 504393 is a highly selective CCR2 chemokine receptor antagonist, with IC50 values of 89 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors, respectively. |
| M1971 | Maraviroc | Maraviroc (UK-427857) is a selective CCR5 antagonist with potent anti-human immunodeficiency virus type 1 (HIV-1) activity and favorable pharmacological properties. |
| M9944 | 7,4'-Dihydroxyflavone | 7,4'-Dihydroxyflavone, a flavonoid isolated from Glycyrrhiza uralensis, is an eotaxin/CCL11 inhibitor. |
| M9884 | INCB3284 | INCB3284 is a potent, selective, and orally bioavailable hCCR2 antagonist, exhibited an IC50 of 3.7 nM in antagonism of monocyte chemoattractant protein-1 binding to hCCR2. |
| M9444 | Cenicriviroc Mesylate | Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, and it also inhibits both HIV-1 and HIV-2. |
| M9135 | TAK-779 | TAK-779 is a potent and selective nonpeptide antagonist of CCR5, with a Ki of 1.1 nM for CCR5. |
| M9131 | ZK-756326 dihydrochloride | ZK-756326 dihydrochloride is a potent, selective and non-peptide CCR8 chemokine receptor agonist. |
| M9006 | NSC5844 | NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic properties. |
| M8986 | CCX140 | CCX140 is a potent CCR2 antagonist. |
| M8257 | SB 328437 | SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM. SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. SB 328437 suppresses the Th2-mediated eosinophil infiltration in the airways. |
| M8254 | SB 297006 | SB 297006 is an antagonist of CCR3 with IC50 of 39 nM. |
| M7218 | RS102895 hydrochloride | RS102895 hydrochloride is a cCR2b chemokine receptor antagonist. |
| M6547 | BX 471 | BX 471 is a potent, selective CCR1 antagonist. |
| M6263 | INCB3284 dimesylate | INCB 3284 dimesylate is a potent, selective and orally bioavailable hCCR2 antagonist with IC50 of 3.7 nM. |
| M6249 | BMS-813160 | BMS-813160 is the first dual CCR2/CCR5 antagonist. BMS-813160 binds with CCR2, CCR5, CCR1, CCR4 and CXCR2 with IC50s of 6.2 nM, 3.6 nM, ＞25 μM, ＞40 μM and ＞40 μM, respectively. |
| M2098 | Bindarit | Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8. Bindarit also has anti-inflammatory activity. |
| M2032 | Vicriviroc Malate | Vicriviroc (SCH 417690) is a pyrimidine CCR5 entry inhibitor of HIV-1 with IC50 of 0.91 nM. |
| M1971 | Maraviroc | Maraviroc (UK-427857) is a selective CCR5 antagonist with potent anti-human immunodeficiency virus type 1 (HIV-1) activity and favorable pharmacological properties. |
| M56340 | AZD-5672 | AZD-5672 is an orally active, potent, and selective CCR5 antagonist (IC50=0.32 nM). |
| M56163 | MLN3126 | MLN3126 is an orally active and potent CCR9 antagonist. |
| M56162 | AZD2423 | AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator. |
| M56161 | AZD-1678 | AZD-1678 is a potent CCR4 receptor antagonist, with a pIC50 of 8.6. |
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