Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M7224 | RS 504393 | RS 504393 is a highly selective CCR2 chemokine receptor antagonist, with IC50 values of 89 nM and > 100 μM for inhibition of human recombinant CCR2 and CCR1 receptors, respectively. |
| M1971 | Maraviroc | Maraviroc (UK-427857) is a selective CCR5 antagonist with potent anti-human immunodeficiency virus type 1 (HIV-1) activity and favorable pharmacological properties. |
| M6249 | BMS-813160 | BMS-813160 is the first dual CCR2/CCR5 antagonist. BMS-813160 binds with CCR2, CCR5, CCR1, CCR4 and CXCR2 with IC50s of 6.2 nM, 3.6 nM, ＞25 μM, ＞40 μM and ＞40 μM, respectively. |
| M13926 | INCB3344 | INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity. |
| M13925 | GW 766994 | GW 766994 (GW 994) is an orally active and specific chemokine receptor-3 (CCR3) antagonist. GW 766994 has the potential for asthma and eosinophilic bronchitis research. |
| M13924 | CCR6 inhibitor 1 | CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). |
| M13923 | CCR2-RA-[R] | CCR2-RA-[R] is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC50 of 103 nM. |
| M13922 | BX471 hydrochloride | BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with Ki of 1 nM for human CCR1, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. |
| M13921 | AZD2098 | AZD2098 is a potent and selective CC-chemokine receptor 4 (CCR4) inhibitor with pIC50s of 7.8, 8.0, 8.0 and 7.6 for human, rat, mouse and dog respectively, used for asthma research. |
| M13920 | AZ084 | AZ084 is a potent, selective, allosteric and oral active CCR8 antagonist, with a Ki of 0.9 nM. Has potential to treat asthma. |
| M11028 | RS102895 | RS102895 is a potent CCR2 antagonist, with IC50 value of 360 nM. |
| M10190 | Cenicriviroc | Cenicriviroc, also known as TAK-652 and TBR-652, is an orally active, dual antagonist of CCR2/CCR5. |
| M9944 | 7,4'-Dihydroxyflavone | 7,4'-Dihydroxyflavone, a flavonoid isolated from Glycyrrhiza uralensis, is an eotaxin/CCL11 inhibitor. |
| M9884 | INCB3284 | INCB3284 is a potent, selective, and orally bioavailable hCCR2 antagonist, exhibited an IC50 of 3.7 nM in antagonism of monocyte chemoattractant protein-1 binding to hCCR2. |
| M9444 | Cenicriviroc Mesylate | Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, and it also inhibits both HIV-1 and HIV-2. |
| M9135 | TAK-779 | TAK-779 is a potent and selective nonpeptide antagonist of CCR5, with a Ki of 1.1 nM for CCR5. |
| M9131 | ZK-756326 dihydrochloride | ZK-756326 dihydrochloride is a potent, selective and non-peptide CCR8 chemokine receptor agonist. |
| M9006 | NSC5844 | NSC5844 (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic properties. |
| M8986 | CCX140 | CCX140 is a potent CCR2 antagonist. |
| M8257 | SB 328437 | SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM. SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. SB 328437 suppresses the Th2-mediated eosinophil infiltration in the airways. |
| M8254 | SB 297006 | SB 297006 is an antagonist of CCR3 with IC50 of 39 nM. |
| M7218 | RS102895 hydrochloride | RS102895 hydrochloride is a CCR2-selective chemokine receptor antagonist (IC50 values are 0.36 and 17.8 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). |
| M6840 | J-113863 | J-113863 is a potent CCR1 chemokine receptor antagonist with IC50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively. J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). |
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