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Cenicriviroc Mesylate

Cat. No. M9444

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Cenicriviroc Mesylate Structure
Synonym:

TBR-652 Mesylate; TAK-652 Mesylate

Size Price Availability Quantity
10mg USD 255  USD255 In stock
25mg USD 510  USD510 In stock
50mg USD 830  USD830 In stock
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Quality Control & Documentation
Biological Activity

Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, and it also inhibits both HIV-1 and HIV-2. Cenicriviroc Mesylate shows a median EC50 of 0.39 nM for the four R5-tropic HIV-2 isolates. Cenicriviroc Mesylate (CVC) treatment leads to dose-related decrease in monocyte/macrophage recruitment, and achieving statistical significance at doses ≥20 mg/kg/day (p<0.05).

Chemical Information
Molecular Weight 793.05
Formula C42H56N4O7S2
CAS Number 497223-28-6
Solubility (25°C) DMSO ≥ 80 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Lefebvre E, et al. PLoS One. Antifibrotic Effects of the Dual CCR2/CCR5 Antagonist Cenicriviroc in Animal Models of Liver and Kidney Fibrosis.

[2] Visseaux B, et al. PLoS One. Cenicriviroc, a Novel CCR5 (R5) and CCR2 Antagonist, Shows In Vitro Activity against R5 Tropic HIV-2 Clinical Isolates.

[3] Lalezari J, et al. J Acquir Immune Defic Syndr. Safety, efficacy, and pharmacokinetics of TBR-652, a CCR5/CCR2 antagonist, in HIV-1-infected, treatment-experienced, CCR5 antagonist-naive subjects.

[4] Baba M, et al. Antimicrob Agents Chemother. TAK-652 inhibits CCR5-mediated human immunodeficiency virus type 1 infection in vitro and has favorable pharmacokinetics in humans.

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Keywords: Cenicriviroc Mesylate, TBR-652 Mesylate; TAK-652 Mesylate supplier, CCR, inhibitors, activators

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