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Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, and it also inhibits both HIV-1 and HIV-2. Cenicriviroc Mesylate shows a median EC50 of 0.39 nM for the four R5-tropic HIV-2 isolates. Cenicriviroc Mesylate (CVC) treatment leads to dose-related decrease in monocyte/macrophage recruitment, and achieving statistical significance at doses ≥20 mg/kg/day (p<0.05).
| Molecular Weight | 793.05 |
| Formula | C42H56N4O7S2 |
| CAS Number | 497223-28-6 |
| Solubility (25°C) | DMSO ≥ 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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