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GSK2239633A 

Cat. No. M28023

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GSK2239633A  Structure

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Quality Control & Documentation
Biological Activity

GSK2239633A is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96 ± 0.11.

Chemical Information
Molecular Weight 549.06
Formula C24H25ClN4O5S2
CAS Number 1240516-71-5
Form Solid
Solubility (25°C) DMSO ≥ 250 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Anthony Cahn, et al. BMC Pharmacol Toxicol. Safety, tolerability, pharmacokinetics and pharmacodynamics of GSK2239633, a CC-chemokine receptor 4 antagonist, in healthy male subjects: results from an open-label and from a randomised study

[2] Panayiotis A Procopiou, et al. J Med Chem. Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists

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  Catalog
Abmole Inhibitor Catalog




Keywords: GSK2239633A  supplier, CCR, inhibitors, activators

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