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TH1760 is an inhibitor of NUDIX-type 15 (NUDT15) with an IC50 value of 25 nM. TH1760 sensitizes cells to 6-thioguanine by enhancing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 enhances the anti-leukemia effect of thiopurine.
| Molecular Weight | 426.45 |
| Formula | C20H18N4O5S |
| CAS Number | 2567914-01-4 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
[2] Si Min Zhang, et al. Nat Chem Biol. Development of a chemical probe against NUDT15
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