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PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells.
| Molecular Weight | 584.67 |
| Formula | C32H36N6O5 |
| CAS Number | 204067-01-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 115 mg/mL (ultrasonic) |
| Storage | 4°C, sealed |
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