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SR-717

Cat. No. M9923
SR-717 Structure
Synonym:

SR-717 lithium

Size Price Availability Quantity
10mg USD 220 In stock
25mg USD 400 In stock
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Quality Control
Biological Activity

SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 351.19
Formula C15H8F2LiN5O3
CAS Number 2375421-09-1
Purity >99%
Solubility DMSO 35 mg/mL
Storage at -20°C
References

Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic
Emily N Chin, et al. Science. 2020 Aug 21;369(6506):993-999. PMID: 32820126.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SR-717, SR-717 lithium supplier, STING, inhibitors

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