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C-178

Cat. No. M10125
C-178 Structure
Synonym:

C178

Size Price Availability Quantity
5mg USD 200 In stock
10mg USD 300 In stock
25mg USD 500 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation. C-178 targets the poorly characterized N-terminal portion of mmSTING that includes the transmembrane domains. C-178 decreases cdG, dsDNA, CMA and LPS-induced Ifnb1 expression in mouse bone marrow-derived macrophages.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 322.27
Formula C17H10N2O5
CAS Number 329198-87-0
Purity >99%
Solubility DMSO ≥ 35 mg/mL
Storage at -20°C
References

Targeting STING with covalent small-molecule inhibitors
Simone M Haag, et al. Nature. 2018 Jul;559(7713):269-273. PMID: 29973723.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: C-178, C178 supplier, STING, inhibitors

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