Free shipping on all orders over $ 500
C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation. C-178 targets the poorly characterized N-terminal portion of mmSTING that includes the transmembrane domains. C-178 decreases cdG, dsDNA, CMA and LPS-induced Ifnb1 expression in mouse bone marrow-derived macrophages.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | 322.27 |
| Formula | C17H10N2O5 |
| CAS Number | 329198-87-0 |
| Purity | >99% |
| Solubility | DMSO ≥ 35 mg/mL |
| Storage | at -20°C |
Targeting STING with covalent small-molecule inhibitors
Simone M Haag, et al. Nature. 2018 Jul;559(7713):269-273. PMID: 29973723.
| Related STING Products |
|---|
| c-di-AMP
c-di-AMP (Cyclic diadenylate) is a STING agonist, it binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway. |
| H-151
H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation. |
| SR-717
SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. |
| C-176
C-176 is a potent small-molecule inhibitor of STING. |
| diABZI STING agonist 1 (compound 3)
diABZI STING agonist-1 (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.
