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C-178

Cat. No. M10125

All AbMole products are for research use only, cannot be used for human consumption.

C-178 Structure
Synonym:

C178

Size Price Availability Quantity
5mg USD 80  USD80 In stock
10mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

C-178 is a covalent inhibitor of STING, binds to Cys91 on STING to block its palmitoylation. C-178 targets the poorly characterized N-terminal portion of mmSTING that includes the transmembrane domains. C-178 decreases cdG, dsDNA, CMA and LPS-induced Ifnb1 expression in mouse bone marrow-derived macrophages.

Chemical Information
Molecular Weight 322.27
Formula C17H10N2O5
CAS Number 329198-87-0
Solubility (25°C) DMSO ≥ 35 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Simone M Haag, et al. Nature. Targeting STING with covalent small-molecule inhibitors

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  Catalog
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Keywords: C-178, C178 supplier, STING, inhibitors, activators

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