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diABZI STING agonist 1 (compound 3)

Cat. No. M9729
diABZI STING agonist 1 (compound 3) Structure
Synonym:

Tautomerism

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10mg USD 776 4-7 Days
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

diABZI STING agonist-1 (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. In vivo, diABZI STING agonist-1 (Tautomerism) induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 849.95
Formula C42H51N13O7
CAS Number 2138498-18-5
Purity >99%
Solubility DMSO ≥ 90 mg/mL
Storage at -20°C
References

Design of amidobenzimidazole STING receptor agonists with systemic activity
Joshi M Ramanjulu, et al. Nature. 2018 Dec;564(7736):439-443. PMID: 30405246.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: diABZI STING agonist 1 (compound 3), Tautomerism supplier, STING, inhibitors

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