All AbMole products are for research use only, cannot be used for human consumption.
3',3'-cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. 3',3'-cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.
| Molecular Weight | 674.41 |
| Formula | C20H24N10O13P2 |
| CAS Number | 849214-04-6 |
| Form | Solid |
| Solubility (25°C) | Water ≥ 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Skrnjug I, et al. PLoS One. Cyclic GMP-AMP displays mucosal adjuvant activity in mice.
| Related STING Products |
|---|
| SN-011
SN-011 is a potent and selective mouse and human STING inhibitor, with an IC50 of 76 nM for STING signaling. |
| IACS-8779
IACS-8779 is a highly potent stimulator of interferon genes (STING) agonist with robust systemic antitumor efficacy. |
| IACS-8803
IACS-8803 is a highly potent cyclic dinucleotide STING agonist with robust systemic antitumor efficacy. |
| STING-IN-6
STING-IN-6 is a potent STING inhibitor with a pIC50 of 8.9. |
| MSA-2 dimer
MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
