Cyclic-di-GMP (c-di-GMP) is a STING activator and a ubiquitous second messenger that regulates biofilm formation, motility, and virulence in diverse bacterial species.
Molecular Weight | 690.41 |
CAS Number | 61093-23-0 |
Solubility (25°C) | Water ≥ 25 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Ramon Hochstrasser, et al. Legionella quorum sensing meets cyclic-di-GMP signaling
[3] Cherisse L Hall, et al. Cyclic-di-GMP regulation of virulence in bacterial pathogens
[4] Ute Rmling, et al. Discovery of the Second Messenger Cyclic di-GMP
[5] Urs Jenal, et al. Cyclic di-GMP: second messenger extraordinaire
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