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| Cat.No. | Name | Information |
|---|---|---|
| M2952 | PMSF | PMSF is an irreversible serine/cysteine protease inhibitor. |
| M25402 | Enlicitide chloride | Enlicitide (MK-0616) chloride is an oral PCSK9 macrocyclic peptide inhibitor. |
| M25117 | Galegenimab | Galegenimab (FHTR 2163; RG 6147; RO 7171009), an anti-High-temperature requirement A1 (HTRA1) antibody fragment. Galegenimab can be used for age-related macular degeneration (AMD) research. |
| M25092 | Recaticimab | Recaticimab (SHR-1209) is a humanized monoclonal antibody that inhibits PCSK9. Receticimab mediates the degradation of PCSK9 by binding to PCSK9, increasing the level of low-density lipoprotein (LDL) receptors on the surface of hepatocytes, reducing the level of LDL in plasma, and achieving the goal of lowering blood lipids. Recaticimab has potential application in hypercholesterolemia. |
| M25040 | Lerodalcibep | Lerodalcibep (LIB003) is a recombinant fusion protein of a PCSK9-binding domain (adnectin) and human serum albumin. Lerodalcibep is a Lipid-lowering agent. Lerodalcibep can be used for the research of hypercholesterolemia and cardiovascular diseases. |
| M24997 | Tafolecimab | Tafolecimab (IBI-306) is a human lgG2 monoclonal antibody that specifically binds PCSK-9 and reduces LDL-C levels by inhibiting PCSK-9-mediated endocytosis of the LDL receptor, which in turn enhances clearance of LDL-C and leads to a reduction in LDL-C levels. Tafolecimab may be used in studies of hypercholesterolaemia. |
| M24947 | Ongericimab | Ongericimab (JS002) is a humanized anti-PCSK9 monoclonal antibody. Ongericimab has lipid-lowering efficacy. Ongericimab can be used in research of hypercholesteremia and hyperlipidemia. |
| M24769 | Frovocimab | Frovocimab (LY 3015014) is a humanized IgG4 monoclonal antibody (mAb) that neutralizes PCSK9. Frovocimab inhibits PCSK9 binding to LDL receptor (LDLR) while permitting the normal proteolytic cleavage of the bound intact PCSK9. |
| M24667 | Lanadelumab | Lanadelumab (SHP643) is a humanized IgG1 monoclonal antibody against plasma kallikrein (pKal) with an Ki value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema. |
| M24651 | Ralpancizumab | Ralpancizumab is a selective PCSK9 inhibitor with potential application in hemorrhagic stroke. |
| M24650 | Bococizumab | Bococizumab (PF-04950615) is an anti-human PCSK9 inhibitory antibody that reduces LDL cholesterol levels. Bococizumab can be used in the research of hypercholesterolemia. |
| M21530 | Sebetralstat | Sebetralstat is an oral, on-demand plasma adrenalin trophin (PKa) inhibitor for hereditary angioedema (HAE). It can be used in the study of acute attacks. |
| M21037 | HPK1-IN-2 | HPK1-IN-2 is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1, a serine/threonine Ste20-related protein kinase), Lck and Flt3 with IC50 of <0.05 μM, IC50 of <0.5 μM and IC50 of <0.05 μM, respectively. HPK1-IN-2 exhibits antitumor activity. |
| M20773 | BioE-1115 | BioE-1115 is a highly selective and potent dual inhibitor of PAS kinase (PASK) and casein kinase 2α (CK2α) with IC50 of ~4 nM and ~10 μM, respectively. |
| M20578 | PF-6260933 | PF-6260933 is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity. |
| M20558 | 6-(Dimethylamino)purine | 6-Dimethylaminopurine is a serine threonine protein kinase inhibitor. It inhibits the germinal vesicle breakdown and the meiotic maturation of oocytes. |
| M20440 | Benzamidine HCl | Benzamidine is an inhibitor of serine proteases with Ki values of 35, 350, and 220 µM for trypsin, plasmin, and thrombin, respectively. |
| M20370 | WAY-230563 | WAY-230563 is a serine/threonine kinase inhibitor. |
| M20292 | WYE-176092 | WYE-176092 is a Inhibitor of mycobacterial serine/threonine protein kinases. |
| M20169 | WAY-355772 | WAY-355772 is a serine/threonine kinase inhibitor. |
| M20033 | WAY-240932 | WAY-240932 is a serine/threonine kinase inhibitor and compns. for increasing the sensitivity of bacterial pathogens to b-lactam antibiotics. |
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