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Cat. No. M21530
Sebetralstat Structure


Size Price Availability Quantity
5mg USD 160  USD160 In stock
10mg USD 250  USD250 In stock
25mg USD 460  USD460 In stock
50mg USD 750  USD750 In stock
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Quality Control & Documentation
Biological Activity

Sebetralstat is an orally active plasma kininase (KLKB1) inhibitor for studies related to hereditary angioedema (HAE).

Chemical Information
Molecular Weight 491.51
Formula C26H26FN5O4
CAS Number 1933514-13-6
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Emel Aygren-Prsn, et al. Lancet. An investigational oral plasma kallikrein inhibitor for on-demand treatment of hereditary angioedema: a two-part, randomised, double-blind, placebo-controlled, crossover phase 2 trial

[2] Rebecca L Davie, et al. J Med Chem. Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema

[3] Peter Mutch, et al. Xenobiotica. Absorption, metabolism, and excretion of [14C]-sebetralstat (KVD900) following a single oral dose in healthy male participants

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Keywords: Sebetralstat, KVD900 supplier, Serine/Threonine Protease, inhibitors, activators

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