| Cat.No. | Name | Information |
|---|---|---|
| M2952 | PMSF | PMSF is an irreversible serine/cysteine protease inhibitor. |
| M3651 | Aprotinin | Aprotinin is a small protein serine protease inhibitor which is used to reduce perioperative blood loss and transfusion. |
| M5219 | AEBSF HCl | AEBSF HCl is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. |
| M28873 | LSP-249 | LSP-249 is a plasma kallikrein inhibitor under the study for angioedema, with an EC50 less than 100 nM in cell. |
| M28166 | PKR-IN-C51 | PKR-IN-C51(compound 51) is an ATP-competitive double-stranded RNA-activated protein kinase (PKR) inhibitor with an IC50 of 9 μM. PKR-IN-C51 inhibits intracellular PKR activation in a dose-dependent manner in primary mouse macrophages. |
| M28118 | Cyclotheonamide A | Cyclotheonamide A is a serine protease inhibitor (cyclic polypeptide), which can be obtained from marine sponges of the genus Theonella. Cyclotheonamide A shows potent inhibitory activity against trypsin (Ki=0.023 µM) and streptokinase (Ki=0.035 µM) and moderate inhibitory activity against human α-thrombin (Ki=0.18 µM). Cyclotheonamide A can be used in study of antithrombotic. |
| M27805 | UCD38B hydrochloride | UCD38B hydrochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC50 value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF). UCD38B hydrochloride induces apoptosis. |
| M25117 | Galegenimab | Galegenimab (FHTR 2163; RG 6147; RO 7171009), an anti-High-temperature requirement A1 (HTRA1) antibody fragment. Galegenimab can be used for age-related macular degeneration (AMD) research. |
| M24667 | Lanadelumab | Lanadelumab (SHP643) is a humanized IgG1 monoclonal antibody against plasma kallikrein (pKal) with an Ki value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema. |
| M21037 | HPK1-IN-2 | HPK1-IN-2 is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1, a serine/threonine Ste20-related protein kinase), Lck and Flt3 with IC50 of <0.05 μM, IC50 of <0.5 μM and IC50 of <0.05 μM, respectively. HPK1-IN-2 exhibits antitumor activity. |
| M20558 | 6-(Dimethylamino)purine | 6-Dimethylaminopurine is a serine threonine protein kinase inhibitor. It inhibits the germinal vesicle breakdown and the meiotic maturation of oocytes. |
| M20440 | Benzamidine HCl | Benzamidine is an inhibitor of serine proteases with Ki values of 35, 350, and 220 µM for trypsin, plasmin, and thrombin, respectively. |
| M20370 | WAY-230563 | WAY-230563 is a serine/threonine kinase inhibitor. |
| M20292 | WYE-176092 | WYE-176092 is a Inhibitor of mycobacterial serine/threonine protein kinases. |
| M20169 | WAY-355772 | WAY-355772 is a serine/threonine kinase inhibitor. |
| M20033 | WAY-240932 | WAY-240932 is a serine/threonine kinase inhibitor and compns. for increasing the sensitivity of bacterial pathogens to b-lactam antibiotics. |
| M14533 | IPR-803 | IPR-803 is a potent inhibitor of the uPAR•uPA protein-protein interaction (PPI). IPR-803 binds directly to uPAR with sub-micromolar affinity. IPR-803 displays anti-tumor activity. |
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