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Benzamidine HCl

Cat. No. M20440
Benzamidine HCl Structure
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Biological Activity

Benzamidine is an inhibitor of serine proteases with Ki values of 35, 350, and 220 µM for trypsin, plasmin, and thrombin, respectively.

Chemical Information
Molecular Weight 156.61
Formula C7H9ClN2
CAS Number 1670-14-0
Solubility (25°C) DMSO 31 mg/mL
Water 31 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Mohamed A Ismail, et al. Bioorg Med Chem. Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents

[2] Yoshiyuki Okumura, et al. Nihon Ishinkin Gakkai Zasshi. Isolation and characterization of a novel acid proteinase, tropiase, from Candida tropicalis IFO 0589

[3] Gianluca Di Profio, et al. J Struct Biol. Trypsin crystallization by membrane-based techniques

[4] No authors listed. Drugs R D. Xemilofiban: SC 54684A, xemlofiban

[5] J E Butler, et al. Oral Microbiol Immunol. Humoral immunity in root caries in an elderly population. 2

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Keywords: Benzamidine HCl supplier, Serine/Threonine Protease, inhibitors, activators

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