Benzamidine is an inhibitor of serine proteases with Ki values of 35, 350, and 220 µM for trypsin, plasmin, and thrombin, respectively.
|Solubility (25°C)||DMSO 31 mg/mL
Water 31 mg/mL
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Mohamed A Ismail, et al. Bioorg Med Chem. Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents
 Yoshiyuki Okumura, et al. Nihon Ishinkin Gakkai Zasshi. Isolation and characterization of a novel acid proteinase, tropiase, from Candida tropicalis IFO 0589
 Gianluca Di Profio, et al. J Struct Biol. Trypsin crystallization by membrane-based techniques
 No authors listed. Drugs R D. Xemilofiban: SC 54684A, xemlofiban
 J E Butler, et al. Oral Microbiol Immunol. Humoral immunity in root caries in an elderly population. 2
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