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Cat. No. M20558
6-(Dimethylamino)purine Structure


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Biological Activity

6-Dimethylaminopurine is a serine threonine protein kinase inhibitor. It inhibits the germinal vesicle breakdown and the meiotic maturation of oocytes.

Chemical Information
Molecular Weight 163.18
Formula C7H9N5
CAS Number 938-55-6
Solubility (25°C) DMSO 32 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Irina V Ogneva, et al. Int J Mol Sci. Sperm of Fruit Fly Drosophila melanogaster under Space Flight

[2] Irina V Ogneva. Curr Issues Mol Biol. Mouse and Fly Sperm Motility Changes Differently under Modelling Microgravity

[3] Jilong Zhou, et al. Aging (Albany NY). Resveratrol delays postovulatory aging of mouse oocytes through activating mitophagy

[4] Karolina Kubiasov, et al. Phytochemistry. Design, synthesis and perception of fluorescently labeled isoprenoid cytokinins

[5] J Nath, et al. Exp Cell Res. Studies on cyclic AMP levels and phosphodiesterase activity in developing sea urchin eggs. Effects of puromycin, 6-dimethylamino purine and aminophylline

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Keywords: 6-(Dimethylamino)purine, N,N-Dimethyladenine supplier, Serine/Threonine Protease, inhibitors, activators

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