| Cat.No. | Name | Information |
|---|---|---|
| M2952 | PMSF | PMSF is an irreversible serine/cysteine protease inhibitor. PMSF is commonly used in the preparation of cell lysates. |
| M3651 | Aprotinin | Aprotinin is a small protein serine protease inhibitor which is used to reduce perioperative blood loss and transfusion. |
| M5219 | AEBSF HCl | AEBSF HCl is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin. |
| M42610 | PCSK9-IN-18 | PCSK9-IN-18 is a potent PCSK9 inhibitor with a KD value of <200 nM. |
| M42609 | Dim16 | Dim16 is a dual PCSK9/HMG-CoAR inhibitor, with an IC50 value of 19 nM for PCSK9. |
| M42608 | PCSK9-IN-15 | PCSK9-IN-15 is a potent inhibitor of proprotein convertase subtilisin/kexin 9 (PCSK9, KD <200 nM). |
| M42607 | AP-C2 | AP-C2 is a potent guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2. |
| M42606 | Benzamidine hydrochloride hydrate | Benzamidine hydrochloride hydrate is a reversible competitive trypsin-like serine proteases inhibitor with Kis of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively. |
| M40917 | Rivulariapeptolides 1121 | Rivulariapeptolides 1121 is a potent and selective serine protease inhibitor with IC50 values of 35.52 nM, 13.24 nM, and 48.05 nM for tryptic coagulase, elastase, and proteinase K, respectively. |
| M40916 | Rivulariapeptolides 1185 | Rivulariapeptolides 1185 is a potent and selective serine protease inhibitor with IC50 values of 13.17 nM, 23.59 nM, and 55.26 nM for tryptic coagulase, elastase, and proteinase K, respectively. |
| M40915 | Rivulariapeptolides 988 | Rivulariapeptolides 988 is a potent and selective serine protease inhibitor with IC50 values of 95.46 nM, 15.29 nM and 85.50 nM for tryptic coagulase, elastase and proteinase K, respectively. |
| M40914 | Rivulariapeptolides 1155 | Rivulariapeptolides 1155 is a potent serine protease inhibitor with IC50 values of 41.84 nM, 4.94 nM, and 56.54 nM for chymotrypsin, elastase, and proteinase K, respectively. |
| M30522 | FOY 251 free base | FOY 251 free base, an anti-proteolytic active metabolite of Camostate, acts as a proteinase inhibitor. FOY 25 free base inhibits SARS-CoV-2 infection in cells assay. |
| M30043 | TPCK | TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium. |
| M29739 | ZK824190 hydrochloride | ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively. |
| M29715 | VD2173 | VD2173 is a side chain cyclized macrocyclic peptide inhibitor of HGF-activating serine proteases. VD2173 potently inhibits matriptase and hepsin. VD2173 can be used for the research of lung cancer. |
| M29468 | Flizasertib | Flizasertib is a serine/threonine kinase inhibitor. |
| M29454 | ZK824190 | ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC50s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively. |
| M29315 | Feniralstat | Feniralstat (compound 30), a pyrazole derivative, is a potent kallikrein inhibitor with an IC50 of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC50>40 μM). |
| M29268 | WNK-IN-1 | WNK-IN-1 (compound 7) is a ATP noncompetitive With-No-Lysine (WNK) kinase inhibitor (IC50=95 nM). WNK-IN-1 can be used to regulate cardiovascular homeostasis. |
| M29266 | WNK-IN-11-d3 | WNK-IN-11-d3 is an orally active, selective and potent With-No-Lysine (WNK) kinase inhibitor. WNK-IN-11-d3 is effective at regulating cardiovascular homeostasis. |
| M29155 | Tilpisertib | Tilpisertib (GS-4875) is a serine/threonine kinase inhibitor (WO2017007689). |
| M28905 | Berotralstat dihydrochloride | Berotralstat dihydrochloride is a low toxicity, effective, highly specific, second-generation, synthetic and orally active plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat dihydrochloride works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. |
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