Rivulariapeptolides 1121 is a potent and selective serine protease inhibitor with IC50 values of 35.52 nM, 13.24 nM, and 48.05 nM for tryptic coagulase, elastase, and proteinase K, respectively.
| Molecular Weight | 1122.31 |
| Formula | C56H83N9O15 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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PCSK9-IN-19 is a PCSK9 inhibitor. |
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| PCSK9-IN-14
PCSK9-IN-14 is a potent PCSK9 inhibitor. |
| PKSI-527
PKSI-527 is a new, highly selective plasma kallikrein inhibitor. |
| PCSK9-IN-18
PCSK9-IN-18 is a potent PCSK9 inhibitor with a KD value of <200 nM. |
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