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Rivulariapeptolides 1121

Cat. No. M40917
Rivulariapeptolides 1121 Structure
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Quality Control & Documentation
Biological Activity

Rivulariapeptolides 1121 is a potent and selective serine protease inhibitor with IC50 values of 35.52 nM, 13.24 nM, and 48.05 nM for tryptic coagulase, elastase, and proteinase K, respectively.

Chemical Information
Molecular Weight 1122.31
Formula C56H83N9O15
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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  Catalog
Abmole Inhibitor Catalog




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