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WNK-IN-11

Cat. No. M14534
WNK-IN-11 Structure
Size Price Availability Quantity
5mg USD 285  USD285 In stock
10mg USD 450  USD450 In stock
25mg USD 750  USD750 In stock
50mg USD 1100  USD1100 In stock
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Quality Control & Documentation
Biological Activity

WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1.

Chemical Information
Molecular Weight 462.4
CAS Number 2123489-30-3
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Viktor N Tomilin, et al. Cells. With-No-Lysine Kinase 1 (WNK1) Augments TRPV4 Function in the Aldosterone-Sensitive Distal Nephron

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  Catalog
Abmole Inhibitor Catalog




Keywords: WNK-IN-11 supplier, Serine/Threonine Protease, inhibitors, activators


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