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Cat. No. M20773
BioE-1115 Structure
Size Price Availability Quantity
5mg USD 60  USD60 In stock
10mg USD 90  USD90 In stock
50mg USD 230  USD230 In stock
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Quality Control & Documentation
Biological Activity

BioE-1115 is a highly selective and potent dual inhibitor of PAS kinase (PASK) and casein kinase 2α (CK2α) with IC50 of ~4 nM and ~10 μM, respectively.

Chemical Information
Molecular Weight 339.36
Formula C19H18FN3O2
CAS Number 1268863-35-9
Solubility (25°C) DMSO 68 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Wojciech Swiatek, et al. Hepatol Commun. Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis

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Keywords: BioE-1115 supplier, Serine/Threonine Protease, inhibitors, activators

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