Berotralstat (BCX7353) was a second generation plasma kallikrein inhibitor with low toxicity and high specificity, and was used for the diagnosis of hereditary angioedema (HAE). Berotralstat works by blocking the enzyme activity of plasma Kallikrein that releases bradykinin, a major biological peptide that promotes swelling and pain associated with HAE attacks.
| Molecular Weight | 562.56 |
| Formula | C30H26F4N6O |
| CAS Number | 1809010-50-1 |
| Form | Solid |
| Storage | 4°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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