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Berotralstat

Cat. No. M11406

All AbMole products are for research use only, cannot be used for human consumption.

Berotralstat  Structure
Size Price Availability
1mg USD 420  USD420 4-7 Days
5mg USD 1240  USD1240 4-7 Days
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Quality Control & Documentation
Biological Activity

Berotralstat (BCX7353) was a second generation plasma kallikrein inhibitor with low toxicity and high specificity, and was used for the diagnosis of hereditary angioedema (HAE). Berotralstat works by blocking the enzyme activity of plasma Kallikrein that releases bradykinin, a major biological peptide that promotes swelling and pain associated with HAE attacks.

Chemical Information
Molecular Weight 562.56
Formula C30H26F4N6O
CAS Number 1809010-50-1
Form Solid
Storage 4°C, dry, sealed
References

[1] No authors listed. Med Lett Drugs Ther. Berotralstat (Orladeyo) for prevention of hereditary angioedema

[2] Michael E Manning, et al. Allergy Asthma Proc. Berotralstat (BCX7353) is a novel oral prophylactic treatment for hereditary angioedema: Review of phase II and III studies

[3] Arnold Lee. Drugs. Berotralstat: First Approval

[4] Isao Ohsawa, et al. Allergy. Oral berotralstat for the prophylaxis of hereditary angioedema attacks in patients in Japan: A phase 3 randomized trial

[5] Bruce Zuraw, et al. J Allergy Clin Immunol. Oral once-daily berotralstat for the prevention of hereditary angioedema attacks: A randomized, double-blind, placebo-controlled phase 3 trial

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Keywords: Berotralstat supplier, Serine/Threonine Protease, inhibitors, activators

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