| Cat.No. | Name | Information |
|---|---|---|
| M2206 | TH-302 (Evofosfamide) | TH-302 is a highly potent and selective hypoxia-activated procompound targeting hypoxic regions of solid tumors with IC50 of 19 nM. |
| M6098 | Baicalein | Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor, IC50 value of 3.12 mM. |
| M9325 | EGTA | EGTA is a specific calcium chelator with a Kd of 60.5 nM at physiological pH (7.4) and a high specificity for Ca2+ than for Mg2+.EGTA significantly inhibits the substrate adhesion capacity of inflammatory macrophages. |
| M9330 | Brij-35 | Brij-35 (Polidocanol) is a high HLB, ethoxylated, nonionic ether of lauryl alcohol with broad pH stability. |
| M6154 | 2-PMPA tetrasodium | 2-PMPA (PMPA tetrasodium salt) is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM. |
| M2250 | Pamidronate disodium | Pamidronate disodium is a nitrogen containing bisphosphonate, used to the research of preventing osteoporosis. |
| M9916 | DPPH | DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that measures the free radical scavenging activity of antioxidants. |
| M9194 | Insulin (human) | Insulin (human) is a polypeptide hormone that regulates the level of sugar (glucose) in the blood and is produced by beta cells of islets. |
| M3409 | Formestane | Formestane is a second generation selective aromatase inhibitor with an IC50 of 80 nM. |
| M9665 | N-(2-amino-2-oxoethyl)acrylamide | N-(2-Amino-2-oxoethyl)acrylamide |
| M21389 | JNJ-55511118 | JNJ-55511118 is an AMPA receptor negative regulator containing transmembrane AMPA receptor regulatory protein γ8 (TARP-γ8). 1 It inhibits glutamate-induced calcium flux in HEK293F cells that were cotransfected with TARP-γ8 and GluA1o, GluA1i, GluA2i, GluA3o, or GluA4o (IC50s = 11.22, 12.3, 7.41, 38.02, and 15.85 nM, respectively). |
| M21385 | Avdoralimab | Avdoralimab (IPH5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1, and blocks C5a/C5aR1 signalling in subsets of myeloid-derived suppressor cells (MDSCs) and neutrophils. It has immunomodulating activity. |
| M21384 | Tesidolumab | Tesidolumab is a fully human monoclonal antibody targeting complement C5. |
| M21380 | MM 07 | MM 07 is a biased apelin receptor agonist with a KD value of 300 nM in CHO-K cells and 172 nM in human heart. |
| M21379 | MK-0354 | MK-0354 is a specific GPR109a receptor agonist, acting on hGPR109a/mGPR109a with EC50 of 1.65 μM and 1.08 μM, respectively, and has no effect on GPR109b. |
| M21377 | PF-06372222 | PF-06372222 is a small-molecule negative allosteric modulator of the glucagon receptor (GCGR). PF-06372222 is also an antagonist for glucagon-like peptide-1 receptor GLP-1R, which inhibits glucagon secretion and glucose-dependent insulin secretion. |
| M21374 | AZ 1729 | AZ1729 is a potent free fatty acid 2 receptor (FFA2) activator that acts as a direct transmutation agonist and a positive transmutation modulator.AZ1729 increases the activity of endogenous short-chain fatty acid propionate in the Gi-mediated pathway but not in the Gq/G11-transduced pathway. |
| M21372 | TP-434 | Eravacycline is an effective broad-spectrum antibacterial agent. |
| M21368 | Fosdenopterin | Fosdenopterin is a molybdenum cofactor deficiency. |
| M21367 | MB-07803 | MB07803 is a potent, non-competitive inhibitor of fructose 1,6-bisphosphatase (FBPase) (EC50: 140 nM, t1/2 of 7.6 ± 2.9 h). |
| M21321 | SPH3127 | SPH3127 is an oral direct renin inhibitor (DRI) that is being developed for hypertension. The renin-angiotensin-aldosterone system is responsible for the regulation of blood pressure. |
| M21315 | lipid 10a | “lipid 10a” (Arcturus tunable lipid for RNA drug delivery). |
| M21311 | BAY 1214784 | BAY 1214784 is a potent, selective and orally active antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R).BAY 1214784 has the potential to be studied in uterine fibroids. |
| M21309 | 3-MORPHOLINOSYDNONIMINE | |
| M21308 | Liperfluo | |
| M21302 | Narasin | Narasin is a cationic ion carrier and anticoccidial agent. narasin inhibits NF-κB signaling and induces apoptosis (tumor cell death), it has activity against gram-positive bacteria, anaerobic bacteria, mycoplasma and coccidia, and it also has antiviral effects. |
| M21301 | Pelacarsen | Pelacarsen (AKCEA-APO(a)-LRx) is a liver-specific, antisense oligonucleotide targeting apolipoprotein(a) that reduces lipoprotein(a) by 80% and is well tolerated. |
| M21300 | Luvadaxistat | Luvadaxistat (TAK-831) is a potential first-in-class D amino acid oxidase (DAAO) inhibitor that could be used in schizophrenia research. |
| M21297 | TP0586352 | TP0586352 is an LpxC inhibitor effective against carbapenem-resistant Klebsiella pneumoniae with no cardiovascular risk. |
| M21295 | PF07059013 | PF07059013 is a non-covalent oral hemoglobin (HbS) modulator. |
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