| Cat.No. | Name | Information |
|---|---|---|
| M2206 | TH-302 (Evofosfamide) | TH-302 is a highly potent and selective hypoxia-activated procompound targeting hypoxic regions of solid tumors with IC50 of 19 nM. |
| M6098 | Baicalein | Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor, IC50 value of 3.12 mM. |
| M9325 | EGTA | EGTA is a specific calcium chelator with a Kd of 60.5 nM at physiological pH (7.4) and a high specificity for Ca2+ than for Mg2+.EGTA significantly inhibits the substrate adhesion capacity of inflammatory macrophages. |
| M9330 | Brij-35 | Brij-35 (Polidocanol) is a high HLB, ethoxylated, nonionic ether of lauryl alcohol with broad pH stability. |
| M6154 | 2-PMPA tetrasodium | 2-PMPA (PMPA tetrasodium salt) is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM. |
| M2250 | Pamidronate disodium | Pamidronate disodium is a nitrogen containing bisphosphonate, used to the research of preventing osteoporosis. |
| M9916 | DPPH | DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable free radical that measures the free radical scavenging activity of antioxidants. |
| M9194 | Insulin (human) | Insulin (human) is a polypeptide hormone that regulates the level of sugar (glucose) in the blood and is produced by beta cells of islets. |
| M3409 | Formestane | Formestane is a second generation selective aromatase inhibitor with an IC50 of 80 nM. |
| M9665 | N-(2-amino-2-oxoethyl)acrylamide | N-(2-Amino-2-oxoethyl)acrylamide |
| M21217 | (-)-JNJ-A07 | (-)-JNJ-A07 is a potent and selective inhibitor of dengue virus (DENV) with an EC50 of 31 nM. |
| M21216 | (+)-JNJ-A07 | (+)-JNJ-A07 is a potent pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 exerts nanomolar to picomolar activity against 21 clinical isolates. (+)-JNJ-A07 has a good pharmacokinetic profile and showed significant efficacy against dengue virus infection in a mouse infection model. |
| M21199 | Intralipid | Intralipid is an emulsion containing soybean oil, glycerol, and soy phosphatides. Intralipid is a safe fat emulsion that can be used as a nutritional supplement. Intralipid effectively inhibits the opening of the mitochondrial permeability transition pore. |
| M21196 | FRM-024 | FRM-024 is a potent CNS-permeable gamma-secretase modulator and a candidate for familial Alzheimer's disease. |
| M21195 | JNJ-67569762 | JNJ-67569762 is a selective BACE1 inhibitor targeting S3 (IC50 = 2.7 nM). It is a preclinical candidate compound for the study of Alzheimer's disease. |
| M21190 | ETX0462 | ETX0462 is a Gram-negative chemotypic antibiotic.ETX0462 has potent in vitro and in vivo activity against Pseudomonas aeruginosa and all other Gram-negative ESKAPE pathogens, Stenotrophomonas maltophilia, and biothreat pathogens. |
| M21179 | TAK-071 | TAK-071 is a novel, potent and selective modulator of muscarinic acetylcholine receptor 1 (M1R) orthostructure. TAK-071 activates M1R with an EC50 of 520 nM. |
| M21174 | Ledaborbactam etzadroxil | Serine_lactamase inhibitor VNRX-7145 is an oral biologic formulation of the boronic acid-containing inhibitor VNRX-5236, currently in Phase I. |
| M21173 | Tanimilast | The M3 antagonist/PDE4 inhibitor dual pharmacology molecule 92a compound is an inhaled compound for lung disease.Tanimilast (CHF-6001) is a novel, potent, selective phosphodiesterase 4 inhibitor (IC50=0.026±0.006 nM) with potent anti-inflammatory activity suitable for topical lung administration. |
| M21170 | LY3202626 | LY3202626, a beta-site APP cleavage enzyme (BACE) inhibitor, is an orally administered, low-dose CNS permeant molecule. |
| M21169 | PF-60873600 | The CDK2/4/6 inhibitor PF-60873600 has oral bioactivity with low Ki values of 0.09 nM, 1.3 nM and 0.16 nM for CDK2, CDK4 and CDK6, respectively. |
| M21164 | Acetyl tetrapeptide-5 | Acetyl tetrapeptide-5 inhibits glycosylation and ACE-1 activity. Acetyl tetrapeptide-5 reduces ocular edema and relieves vascular pressure by improving vascularity and strengthening the eye skin. acetyl tetrapeptide-5 can be used in antioxidant, anti-aging skin care studies. Sequence: Ac-Beta-Ala-His-Ser-His-OH. |
| M21163 | Decapeptide-12 | Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with the C-terminal residue of tyrosinase (Kd: 61.1 μM). decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 µM ). Sequence: YRSRKYSSWY. |
| M21155 | NRX-252262 | NRX-252262 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP and promotes the degradation of β-catenin with an EC50 value of 3.8 nM. |
| M21154 | NRX-252114 | NRX-25211 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, enhancing the binding of pSer33/S37A β-catenin to β-TrCP with an EC50 of 6.5 nM and a Kd of 0.4 nM. NRX-25211 was able to promote the degradation of mutant β catenin degradation. |
| M21144 | JNJ-61803534 | JNJ-61803534 is an orally active RORgt inhibitor, JNJ-61803534 is an oral clinical candidate that is well tolerated in humans up to 200 mg and has shown PD. |
| M21124 | CVN424 | CVN424 is an orally active and selective GPR6 inverse agonist with a Ki of 9.4 nM and an EC50 of 38 nM. CVN424 can cross the blood-brain barrier and has potential for use in Parkinson's disease research. |
| M21123 | S62798 | Thrombin-activatable fibrinolytic inhibitor (TAFIa) inhibitor (S62798) is a fibrinolytic (clot-degrading) agent with an IC50 value of 6 mM. |
| M21122 | NITD-688 | The pan-serotype dengue virus (DENV) NS4B protein inhibitor NITD-688 is a preclinical candidate compound with strong in vitro activity against all four serotypes of dengue virus and excellent oral efficacy. |
| M21120 | SJF-0628 | SJF-0628 is a VHL-based xenofunctional degrader with in vivo activity in xenograft models (50 mg/kg BID IP). |
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