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Tanimilast

Cat. No. M21173

All AbMole products are for research use only, cannot be used for human consumption.

Tanimilast Structure
Synonym:

CHF-6001

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Quality Control & Documentation
Biological Activity

The M3 antagonist/PDE4 inhibitor dual pharmacology molecule 92a compound is an inhaled compound for lung disease.Tanimilast (CHF-6001) is a novel, potent, selective phosphodiesterase 4 inhibitor (IC50=0.026±0.006 nM) with potent anti-inflammatory activity suitable for topical lung administration.

Chemical Information
Molecular Weight 687.54
Formula C30H30Cl2F2N2O8S
CAS Number 1239278-59-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mastiyage R Goonathilake, et al. Cureus. Can Phosphodiesterase 4 Inhibitor Therapy Be Used in Respiratory Diseases Other Than Chronic Obstructive Pulmonary Disease?

[2] Tiziana Schioppa, et al. Int J Mol Sci. The PDE4 Inhibitor Tanimilast Restrains the Tissue-Damaging Properties of Human Neutrophils

[3] Hoang Oanh Nguyen, et al. J Transl Med. The PDE4 inhibitor tanimilast shows distinct immunomodulatory properties associated with a type 2 endotype and CD141 upregulation

[4] Hoang Oanh Nguyen, et al. Front Immunol. The PDE4 Inhibitor Tanimilast Blunts Proinflammatory Dendritic Cell Activation by SARS-CoV-2 ssRNAs

[5] Fabrizio Facchinetti, et al. Front Pharmacol. Tanimilast, A Novel Inhaled Pde4 Inhibitor for the Treatment of Asthma and Chronic Obstructive Pulmonary Disease

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Keywords: Tanimilast, CHF-6001 supplier, inhibitors, activators

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