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CVN424

Cat. No. M21124

All AbMole products are for research use only, cannot be used for human consumption.

CVN424 Structure

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Quality Control & Documentation
Biological Activity

CVN424 is an orally active and selective GPR6 inverse agonist with a Ki of 9.4 nM and an EC50 of 38 nM. CVN424 can cross the blood-brain barrier and has potential for use in Parkinson's disease research.

Chemical Information
Molecular Weight 473.52
Formula C24H29F2N5O3
CAS Number 2254706-21-1
Solubility (25°C) DMSO : 62.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] David H Margolin, et al. J Pharmacol Exp Ther. A Phase I, First-in-Human, Healthy Volunteer Study to Investigate the Safety, Tolerability, and Pharmacokinetics of CVN424, a Novel G Protein-Coupled Receptor 6 Inverse Agonist for Parkinson's Disease

[2] Huikai Sun, et al. J Med Chem. First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson's Disease: Discovery, Pharmacological Validation, and Identification of a Clinical Candidate

[3] Nicola L Brice, et al. J Pharmacol Exp Ther. Development of CVN424: A Selective and Novel GPR6 Inverse Agonist Effective in Models of Parkinson Disease

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