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PF-06372222

Cat. No. M21377

All AbMole products are for research use only, cannot be used for human consumption.

PF-06372222 Structure

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Biological Activity

PF-06372222 is a small-molecule negative allosteric modulator of the glucagon receptor (GCGR). PF-06372222 is also an antagonist for glucagon-like peptide-1 receptor GLP-1R, which inhibits glucagon secretion and glucose-dependent insulin secretion.

Chemical Information
Molecular Weight 515.53
Formula C26H28F3N5O3
CAS Number 1407592-99-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Takahiro Kawai, et al. Proc Natl Acad Sci U S A. Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist

[2] Gaojie Song, et al. Nature. Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

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