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Avdoralimab

Cat. No. M21385

All AbMole products are for research use only, cannot be used for human consumption.

Avdoralimab Structure
Synonym:

anti-hC5aR-32F3A6 GL;IPH-5401

Price and Availability

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Quality Control & Documentation
Biological Activity

Avdoralimab (IPH5401) is a fully human IgGκ monoclonal antibody that targets the complement C5a receptor 1, and blocks C5a/C5aR1 signalling in subsets of myeloid-derived suppressor cells (MDSCs) and neutrophils. It has immunomodulating activity.

Chemical Information
CAS Number 2226393-85-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Julien Carvelli, et al. Crit Care Med. Avdoralimab (Anti-C5aR1 mAb) Versus Placebo in Patients With Severe COVID-19: Results From a Randomized Controlled Trial (FOR COVID Elimination [FORCE])

[2] Catherine J Hutchings. Antib Ther. Mini-review: antibody therapeutics targeting G protein-coupled receptors and ion channels

[3] Marcus Maurer, et al. J Allergy Clin Immunol Pract. Biologics for the Use in Chronic Spontaneous Urticaria: When and Which

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Keywords: Avdoralimab, anti-hC5aR-32F3A6 GL;IPH-5401 supplier, inhibitors, activators

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