| Cat.No. | Name | Information |
|---|---|---|
| M3645 | MG149 | MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM). |
| M2198 | Curcumin | Curcumin (Diferuloyl), a natural phenolic compound, is a p300/CREB binding protein specific inhibitor that inhibits histone/non-histone acetylation and histone acetyltransferase-dependent chromatin transcription. Curcumin inhibited NF-κ B and MAPKs, and had anti-inflammatory, antioxidant, anti-proliferation and anti-angiogenesis effects. Curcumin induces Nrf2 protein stabilization through Keap1 cysteine modification. |
| M55326 | JG-2016 | JG-2016 is a potent inhibitor of histone acetyltransferase 1 (HAT1), with an IC50 of 14.8 μM in the HAT1 acetylation assays. |
| M41677 | KAT6-IN-1 | KAT6-IN-1 is a potent KAT6 inhibitor. |
| M41676 | MC4171 | MC4171 is a first-in-class selective KAT8 inhibitor (IC50=8.1 µM). MC4171 exhibits moderate micromolar antiproliferative activity in different cancer cell lines, including NSCLC and AML, without impacting the viability of nontransformed cells. |
| M40815 | PF-9363 | PF-9363 is a first-in-class, orally active, highly selective KAT6A/B inhibitor for studies related to ER-positive breast cancer. |
| M28625 | PU139 | PU139 is a potent pan-histone acetyltransferase (HAT) inhibitor. PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 with IC50s of 8.39, 9.74, 2.49 and 5.35 μM, respectively. |
| M25562 | TTK21 | TTK21 is an activator of the histone acetyltransferases CBP/p300. TTK21 can cross the blood-brain barrier, and reaches different parts of the brain when conjugated to glucose-based carbon nanosphere (CSP). TTK21 has potential for research of brain neurogenesis and long-term memory function. |
| M25561 | CTB | CTB is a potent p300 histone acetyltransferase activator. CTB induces time dependence apoptosis of MCF-7 cells. |
| M13828 | CTPB | CTPB is a good activator of p300 histone acetyl transferase (HAT) enzyme. |
| M13827 | Butyrolactone 3 | Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. |
| M11175 | WM-3835 | WM-3835 is a potent, highly specific HBO1 (KAT7 or MYST2) inhibitor that binds directly to the acetyl-Coenzyme A binding site of HBO1 33 and WM-3835 activates apoptosis while inhibiting proliferation, migration, and invasion of osteosarcoma (OS) cells. WM-3835 has anti-tumor activity and effectively inhibits the growth of osteosarcoma xenografts in mice. |
| M10585 | WM-1119 | WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM, Kd of 2 nM, WM-1119 is a reversible competitor of acetyl coenzyme A and inhibits MYST-catalysed histone acetylation. |
| M9919 | TH1834 | TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. |
| M9561 | A-485 | A-485 is a potent and selective HAT inhibitor of p300/CBP in vitro with an IC50 of 10 nM in a p300 TR-FRET assay and 3 nM in a CBP TR-FRET assay with selectivity > 1000-fold over closely related HATs. |
| M9469 | WM-8014 | WM-8014, also known as MOZ-IN-3, is a highly potent inhibitor of MOZ with an IC50 of 55 nM. |
| M9445 | YF2 | YF2 is a selective HAT (histone acetyltransferase) activator, with EC50 values of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF and GCN5, respectively. |
| M9410 | Remodelin hydrobromide | Remodelin hydrobromide is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. |
| M7738 | CPTH2 | CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. |
| M7065 | NU9056 | NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an IC50 of 2 µM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells. |
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